Evidence map›Paper›PMID 35562184›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2022

Intracranial paragangliomas versus schwannomas: Role of dynamic susceptibility contrast perfusion and diffusion MRI.

Yoshiaki Ota, Eric Liao, Aristides A Capizzano, Akira Baba, Ryo Kurokawa, Mariko Kurokawa, Ashok Srinivasan

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Intracranial paragangliomas versus schwannomas: Role of dynamic susceptibility contrast perfusion and diffusion MRI.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yoshiaki OtaDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-8992-2156
Eric LiaoDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.
Aristides A CapizzanoDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.
Akira BabaDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-6913-5307
Ryo KurokawaDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-1186-8900
Mariko KurokawaDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-3907-9188
Ashok SrinivasanDepartment of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDifferentiating paragangliomas from schwannomas and distinguishing sporadic from neurofibromatosis type 2 (NF 2)-related schwannomas is challenging but clinically important. This study aimed to assess the utility of dynamic susceptibility contrast perfusion MRI (DSC-MRI) and diffusion-weighted imaging (DWI) in discriminating infratentorial extra-axial schwannomas from paragangliomas and NF2-related schwannomas.

methodsThis retrospective study included 41 patients diagnosed with paragangliomas, sporadic schwannomas, and NF2-related schwannomas in the infratentorial extra-axial space between April 2013 and August 2021. All cases had pretreatment DSC-MRI and DWI. Normalized mean apparent diffusion coefficient (nADCmean), normalized relative cerebral blood volume (nrCBV), and normalized relative cerebral blood flow (nrCBF) were compared between paragangliomas and schwannomas and between sporadic and NF2-related schwannomas as appropriate.

resultsnrCBV and nrCBF were significantly higher in paragangliomas than in sporadic/NF2-related schwannomas (nrCBV: median 11.5 vs. 1.14/3.74; p < .001 and .004, nrCBF: median 7.43 vs. 1.13/2.85; p < .001 and .007, respectively), while nADCmean were not. The corresponding diagnostic performances were area under the curves (AUCs) of .99/.92 and 1.0/.90 with cutoffs of 2.56/4.22 and 1.94/3.36, respectively. nADCmean were lower, and nrCBV and nrCBF were higher in NF2-related than in sporadic schwannomas (nADCmean: median 1.23 vs. 1.58, nrCBV: median 3.74 vs. 1.14, nrCBF: median 2.85 vs. 1.13; all p < .001), and the corresponding diagnostic performances were AUCs of .93, .91, and .95 with cutoffs of 1.37, 2.63, and 2.48, respectively.

conclusionsDSC-MRI and DWI both can aid in differentiating paragangliomas from schwannomas and sporadic from NF2-related schwannomas.

Indexed as

NeurilemmomaNeurofibromatosis 2ParagangliomaDiffusion Magnetic Resonance ImagingHumansPerfusionRetrospective StudiesDSC perfusion MRIDWINF2paragangliomavestibular schwannoma

Identifiers

PMID35562184
PMCPMC9546409
OpenAlexW4280519648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.