Evidence map›Paper›PMID 35562179›Full record

ArticleScientific reports2022

RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1.

Kyle E Harvey, Emily K LaVigne, Mohd Saleem Dar, Amy E Salyer, Evan P S Pratt, Paxton A Sample, Uma K Aryal, Humaira Gowher, Gregory H Hockerman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Cytochrome P450 1a (CYP1A)-Knockout Javanese Medaka Fish Exhibit Diabetic Traits and Reduced Reproductive Capacity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kyle E Harvey *Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Emily K LaVigne *Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Mohd Saleem DarDepartment of Biochemistry, Purdue University, West Lafayette, IN, USA.
Amy E SalyerDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Evan P S PrattDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Paxton A SampleDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
Uma K AryalProteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA.
Humaira GowherDepartment of Biochemistry, Purdue University, West Lafayette, IN, USA.
Gregory H HockermanDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA. gregh@purdue.edu.
Purdue University West Lafayette · US

Funding

Regulation of Dnmt3 Activity at Enhancers of Cell Identity Genes During DifferentiationR01GM118654 · NIGMS · PURDUE UNIVERSITY · PI GOWHER, HUMAIRA · 2017 to 2021
$1.6M
NIGMS NIH HHS R01 GM118654
6 · The paper itself

Abstract

The role of ER Ca

Indexed as

InsulinomaPancreatic NeoplasmsAnimalsCell LineGlucoseInsulinProteomicsRatsRNA, MessengerRyanodine Receptor Calcium Release ChannelGlucoseInsulinRNA, MessengerRyanodine Receptor Calcium Release ChannelRyR2 protein, rat

Identifiers

PMID35562179
PMCPMC9095623
OpenAlexW4280501162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.