Observational studyChest2022
Association of Right Ventricular Afterload With Atrial Fibrillation Risk in Older Adults: The Atherosclerosis Risk in Communities Study.
Observational study in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Prognostic Value of Right Ventricular Performance and Left Atrial Mechanical Efficiency in Paroxysmal Atrial Fibrillation.Journal of cardiovascular development and disease · 2026Article
- Echocardiography Does Not Delay Surgery in Elderly Patients with Hip Fractures, and Pulmonary Hypertension and Decreased Left Ventricular Ejection Fraction Are Associated with In-Hospital Mortality.Journal of clinical medicine · 2026Article
- Incident Atrial Fibrillation and Flutter in Patients With Pulmonary Arterial Hypertension: Influence of Right Ventricular Dilatation and Reduced Right Atrial Function.Journal of the American Heart Association · 2026Observational
- Enhancing atrial fibrillation risk prediction in an observational cohort of tobacco-exposed individuals: the role of pulmonary function tests, symptom scores, and imaging.Respiratory research · 2025Observational
- Incident arrhythmias in relation to ventilatory parameters and pulmonary disease: evidence from two prospective cohort studies.BMC medicine · 2025Article
- Strategies for Recurrent Atrial Fibrillation in Patients Despite Durable Pulmonary Vein Isolation.Journal of clinical medicine · 2025Article
- Exploring the Feasibility of Integrating Cardiopulmonary Exercise Testing, Echocardiography, and Biomarkers for Predicting Atrial Fibrillation Recurrence: Rationale, Design and Protocol for a Prospective Cohort Study (The PLACEBO Trial).Journal of clinical medicine · 2025Article
- Outcomes in Atrial Fibrillation Patients with Different Clinical Phenotypes: Insights from the French Population.Journal of clinical medicine · 2025Article
- Early Detection of Atrial Fibrillation in Chronic Obstructive Pulmonary Disease Patients.Medicina (Kaunas, Lithuania) · 2024Review
- Construction and validation of a risk prediction model for 3- and 5-year new-onset atrial fibrillation in HFpEF patients.Frontiers in cardiovascular medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAtrial fibrillation (AF) is widely perceived to originate from the left atrium (LA). Whether increases in right ventricular (RV) afterload in older adults play an etiological role in AF genesis independent of LA and left ventricular (LV) remodeling is unknown. RESEARCH QUESTION: Is higher RV afterload associated with greater AF risk independent of LA and LV remodeling? STUDY DESIGN AND
methodsIn this observational prospective study, we included 2,246 community-dwelling older adults (mean age, 75 years) without known cardiovascular disease, with LV ejection fraction > 50%, LA volume index < 34 mL/m
resultsDuring follow-up (median, 6.3 years; interquartile interval, 5.5-6.9 years), 215 participants developed AF. AF risk was significantly higher in the third (vs first) tertile of PASP (HR, 1.65; 95% CI, 1.08-2.54) and PVR (HR, 1.38; 95% CI, 1.00-2.08) independent of LA and LV structure and function, heart rate, BMI, prevalent sleep apnea, systemic BP, antihypertensive medications, and lung, kidney, and thyroid function. These associations persisted after further exclusion of participants with tricuspid regurgitation jet velocity > 2.8 m/s and lateral and septal mitral annular velocity above age- and sex-specific reference limits.
interpretationIn older adults, higher RV afterload is associated with greater AF risk independent of LA and LV remodeling. Future research should focus on confirming this novel association and elucidate underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.