Evidence map›Paper›PMID 35561818›Full record

ArticleBiological psychology2022

Associations between aerobic exercise and dopamine-related reward-processing: Informing a model of human exercise engagement.

Sasha Gorrell, Megan E Shott, Guido K W Frank

Open access · hybridAbstract read
In one paragraph

Article in Biological psychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sasha GorrellDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, United States.
Megan E ShottDepartment of Psychiatry, University of California, San Diego, CA, United States.
Guido K W FrankDepartment of Psychiatry, University of California, San Diego, CA, United States. Electronic address: gfrank@health.ucsd.edu.
University of California, San Diego · USUniversity of California, San Francisco · US

Funding

Taste reward circuits and prediction error define eating disorder psychopathologyR01MH103436 · NIMH · UNIVERSITY OF COLORADO DENVER · PI STODDARD, JOEL JOHNSON · 2014 to 2018
$2.0M
UCSD Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Faculty Development ProgramR25NS117367 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Victoria B Risbrough, Joann Trejo · 2020 to 2026
$1.6M
Brain Reward Circuits and Computational Modeling in Adolescent Anorexia NervosaR01MH096777 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FRANK, GUIDO KW · 2012 to 2016
$1.5M
Neural Correlates of Reinforcement Learning Specific to Hyperactivityin Adolescent Anorexia NervosaK23MH126201 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORRELL, SASHA CATHERINE · 2021 to 2025
$848k
NIMH NIH HHS K23 MH126201NIMH NIH HHS R01 MH096777NIMH NIH HHS R01 MH103436NINDS NIH HHS R25 NS117367
6 · The paper itself

Abstract

Endurance or aerobic exercise has many physical and mental health benefits, but less is known about the specific impact that cardiovascular activity may have on dopamine-associated brain circuits involved in reward processing and mood regulation in humans. Understanding such effects will help to explain individual differences in both exercise uptake and maintenance. This study evaluated neural response to a classical taste-conditioning reward prediction error task with the use of functional magnetic resonance imaging, along with data on self-reported aerobic exercise among healthy young adult females (N = 111). Results indicated positive associations between reported aerobic exercise and regional brain response that remained significant after multiple comparison correction for the right medial orbital frontal cortex response to unexpected sucrose receipt (r = 0.315, p = .0008). The medial orbitofrontal cortex is implicated in reward and outcome value computation and the results suggest that aerobic exercise may strengthen this circuitry, or reciprocally, higher orbitofrontal cortical activity may reinforce exercise behavior. The findings aid in developing a model of how exercise engagement can modify reward-circuit function and could be used therapeutically in conditions associated with altered brain salience response.

Indexed as

DopamineRewardBrainExerciseFemaleHumansMagnetic Resonance ImagingPrefrontal CortexYoung AdultDopamineDopamineExerciseOrbitofrontal cortexReward omissionReward prediction errorReward receipt

Identifiers

PMID35561818
PMCPMC9869713
OpenAlexW4280603497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.