Evidence map›Paper›PMID 35561686›Full record

ArticleCell2022

The genomic origins of the world's first farmers.

Nina Marchi, Laura Winkelbach, Ilektra Schulz, Maxime Brami, Zuzana Hofmanová, Jens Blöcher, Carlos S Reyna-Blanco, Yoan Diekmann, Alexandre Thiéry, Adamandia Kapopoulou and 21 more

Abstract readHistorical Article
In one paragraph

Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Appreciating diversity: a review of the Iranian genomic landscape.European journal of human genetics : EJHG · 2026
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  11. Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026
    Article
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  17. Inference of human pigmentation from ancient DNA by genotype likelihoods.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Review
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Nina MarchiCMPG, Institute for Ecology and Evolution, University of Berne, 3012 Berne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Laura WinkelbachPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Ilektra SchulzSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Maxime BramiPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Zuzana HofmanováSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland; Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany; Department of Archaeology and Museology, Faculty of Arts, Masaryk University, 60200 Brno, Czech Republic.
Jens BlöcherPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Carlos S Reyna-BlancoSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Yoan DiekmannPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany; Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.
Alexandre ThiéryCMPG, Institute for Ecology and Evolution, University of Berne, 3012 Berne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Adamandia KapopoulouCMPG, Institute for Ecology and Evolution, University of Berne, 3012 Berne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Vivian LinkSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland.
Valérie PiuzCMPG, Institute for Ecology and Evolution, University of Berne, 3012 Berne, Switzerland.
Susanne KreutzerPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Sylwia M FigarskaPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Elissavet GaniatsouLaboratory of Physical Anthropology, Department of History and Ethnology, Democritus University of Thrace, 69100 Komotini, Greece.
Albert PukajPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany.
Travis J StruckDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Ryan N GutenkunstDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
Necmi KarulDepartment of Prehistory, İstanbul University, 34434 Istanbul, Turkey.
Fokke GerritsenNetherlands Institute in Turkey, 34433 Istanbul, Turkey; Vrije Universiteit, 1081 HV Amsterdam, the Netherlands.
Joachim PechtlInstitute of Archaeology, Innsbruck University, 6020 Innsbruck, Austria.
Joris PetersArchaeoBioCenter and Institute of Palaeoanatomy, Domestication Research and the History of Veterinary Medicine, LMU Munich, 80539 Munich, Germany; SNSB, State Collection of Palaeoanatomy Munich, 80333 Munich, Germany.
Andrea Zeeb-LanzGeneraldirektion Kulturelles Erbe Rheinland-Pfalz, Dir. Landesarchäologie, 67346 Speyer, Germany.
Eva LenneisDepartment of Prehistoric and Historical Archaeology, University of Vienna, 1190 Vienna, Austria.
Maria Teschler-NicolaDepartment of Anthropology, Natural History Museum of Vienna, 1010 Vienna, Austria; Department of Evolutionary Anthropology, University of Vienna, 1030 Vienna, Austria.
Sevasti TriantaphyllouDepartment of History and Archaeology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Sofija StefanovićDepartment of Archaeology, Laboratory for Bioarchaeology, University of Belgrade, 11000 Belgrade, Serbia.
Christina PapageorgopoulouLaboratory of Physical Anthropology, Department of History and Ethnology, Democritus University of Thrace, 69100 Komotini, Greece.
Daniel WegmannSwiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland. Electronic address: daniel.wegmann@unifr.ch.
Joachim BurgerPalaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg University Mainz, 55099 Mainz, Germany. Electronic address: jburger@uni-mainz.de.
Laurent ExcoffierCMPG, Institute for Ecology and Evolution, University of Berne, 3012 Berne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland. Electronic address: laurent.excoffier@iee.unibe.ch.

Funding

Joint inferences of natural selection between sites and populationsR01GM127348 · NIGMS · UNIVERSITY OF ARIZONA · PI GUTENKUNST, RYAN · 2019 to 2023
$1.7M
NIGMS NIH HHS R01 GM127348
6 · The paper itself

Abstract

The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multiphase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene.

Indexed as

FarmersGenomeAgricultureDNA, MitochondrialEuropeGenetic DriftGenomicsHistory, AncientHuman MigrationHumansDNA, Mitochondrialancient genomicsdemogenomic modelingdemographic inferencedemographic processeshuman evolutionNeolithic transitionpopulation admixtureupper Palaeolithic

Identifiers

PMID35561686
PMCPMC9166250

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