Evidence map›Paper›PMID 35561334›Full record

ArticleJournal of the American Chemical Society2022

Biocatalytic Carbene Transfer Using Diazirines.

Nicholas J Porter, Emma Danelius, Tamir Gonen, Frances H Arnold

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
  2. Biocatalytic Regioselective C-Formylation of Resorcinol Derivatives.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Review
  4. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  5. Article
  6. Article
  7. The Versatility of Diazirines: Properties, Synthetic and Modern Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Review
  8. Standards for MicroED.Acta crystallographica. Section C, Structural chemistry · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. C-H Insertion from Isolable Copper Benzylidenes.Journal of the American Chemical Society · 2024
    Article
  13. Biocatalytic Synthesis of α-Amino Esters via Nitrene C-H Insertion.Journal of the American Chemical Society · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Enzymatic Nitrogen Incorporation Using Hydroxylamine.Journal of the American Chemical Society · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicholas J PorterDivision of Chemistry and Chemical Engineering, Division of Biology and Bioengineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, California 91125, United States.ORCID 0000-0002-9803-5310
Emma DaneliusHoward Hughes Medical Institute, University of California Los Angeles, Los Angeles, California 90095, United States.
Tamir GonenHoward Hughes Medical Institute, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-9254-4069
Frances H ArnoldDivision of Chemistry and Chemical Engineering, Division of Biology and Bioengineering, California Institute of Technology, 1200 East California Boulevard, MC 210-41, Pasadena, California 91125, United States.ORCID 0000-0002-4027-364X

Funding

TRD4: Design and Engineering of MicroED hardware for nanocrystallization and time resolved studiesP41GM136508 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GONEN, TAMIR, NANNENGA, BRENT · 2020 to 2024
$7.6M
NIGMS NIH HHS P41 GM136508
6 · The paper itself

Abstract

Biocatalytic carbene transfer from diazo compounds is a versatile strategy in asymmetric synthesis. However, the limited pool of stable diazo compounds constrains the variety of accessible products. To overcome this restriction, we have engineered variants of

Indexed as

DiazomethaneMethaneAzo CompoundsBiocatalysisCatalysisAzo CompoundscarbeneDiazomethaneMethane

Identifiers

PMID35561334
PMCPMC9205183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.