ArticleProceedings of the National Academy of Sciences of the United States of America2022
Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Investigating the Cognitive Neural Mechanisms of Socially Shared Retrieval-Induced Forgetting: Insights from Behavioral and Electrophysiological Evidence.Brain sciences · 2026Article
- The circuitry regulation of associative learning: dissociated and integrated function of the perirhinal cortex and hippocampus.Frontiers in neural circuits · 2026Review
- Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Hippocampal systems for event encoding and sequencing during ongoing narrative comprehension.Communications biology · 2025Article
- Synchronous Theta Networks Characterize Successful Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Social subordination is associated with better cognitive performance and higher theta coherence of the mPFC-vHPC circuit in male rats.PloS one · 2025Article
- [A study on the effects of learning on the properties of rats hippocampal-prefrontal connections in a memory task].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- From Fundamentals to Innovation in Alzheimer's Disease: Molecular Findings and Revolutionary Therapies.International journal of molecular sciences · 2024Review
- Olfactory bulb stimulation mitigates Alzheimer's-like disease progression.CNS neuroscience & therapeutics · 2024Article
- Functional architecture of the forebrain cholinergic system in rodents.Research square · 2024Article
- Border cells without theta rhythmicity in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Enhanced Novel Object Recognition and Spatial Memory in Rats Selectively Bred for High Nicotine Preference.Brain sciences · 2024Article
- Mystery of the memory engram: History, current knowledge, and unanswered questions.Neuroscience and biobehavioral reviews · 2024Review
- Article
- Effects of sex and pro-inflammatory cytokines on context discrimination memory.Behavioural brain research · 2023Article
- Rats use strategies to make object choices in spontaneous object recognition tasks.Scientific reports · 2022Article
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3 authors.
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Abstract
Remembering life episodes is a complex process that requires interaction among multiple brain areas. It is thought that contextual information provided by the hippocampus (HPC) can trigger the recall of a past event through the activation of medial prefrontal cortex (mPFC) neuronal ensembles, but the underlying mechanisms remain poorly understood. However, little is known about the coordinated activity between these structures during recall. We performed electrophysiological recordings in behaving rats during the retrieval phase of the object-in-context (OIC) memory task. Context-guided recognition of objects in this task requires the activity of both the mPFC and the ventral HPC (vHPC). Coherence, phase locking, and theta amplitude correlation analysis showed an increase in vHPC-mPFC LFP synchronization in the theta range when animals explore contextually mismatched objects. Moreover, we identified ensembles of putative pyramidal cells in the mPFC that encode specific object–context associations. Interestingly, the increase of vHPC-mPFC synchronization during exploration of the contextually mismatched object and the preference of mPFC incongruent object neurons predicts the animals’ performance during the resolution of the OIC task. Altogether, these results identify changes in vHPC-mPFC synchronization and mPFC ensembles encoding specific object–context associations likely involved in the recall of past events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.