Evidence map›Paper›PMID 35561022›Full record

ArticlePhysiological reports2022

Sirt1 overexpression attenuates Western-style diet-induced aortic stiffening in mice.

Venkateswara R Gogulamudi, Daniel R Machin, Grant D Henson, Jisok Lim, Richard C Bramwell, Jessica R Durrant, Anthony J Donato, Lisa A Lesniewski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Venkateswara R GogulamudiDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-8349-6640
Daniel R MachinDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Grant D HensonDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Jisok LimDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Richard C BramwellDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Jessica R DurrantDallas Tissue Research, Dallas, Texas, USA.
Anthony J DonatoDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Lisa A LesniewskiDepartment of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
University of Utah · USFlorida State University · USResearch Institute of Dallas · US

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
Molecular Physiology of the Cardiovascular SystemT32HL007676 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI HAMILTON, SUSAN L · 1989 to 2020
$7.9M
IMPACT OF T CELLS ON AGE-RELATED VASCULAR DYSFUNCTION: A TRANSLATIONAL APPROACH - DIVERSITY SUPPLEMENTR01AG060395 · NIA · UNIVERSITY OF UTAH · PI DONATO, ANTHONY JOHN · 2019 to 2023
$2.5M
Integrative Mechanisms of Vascular AgingR01AG077751 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anthony John Donato, Lisa A Lesniewski · 2023 to 2026
$1.8M
Mechanisms of augmented atherosclerotic progression with agingR01AG048366 · NIA · UNIVERSITY OF UTAH · PI LESNIEWSKI, LISA A · 2016 to 2020
$1.7M
Telomere uncapping and arterial dysfunction: Novel mechanism and implications for agingR01AG050238 · NIA · UNIVERSITY OF UTAH · PI DONATO, ANTHONY JOHN · 2016 to 2020
$1.6M
The role of hyaluronan in age-related vascular and skeletal muscle dysfunctionR00AT010017 · NCCIH · FLORIDA STATE UNIVERSITY · PI MACHIN, DANIEL ROBERT · 2020 to 2022
$747k
Amelioration of aged endothelial dysfunction by NAMPT and caloric restrictionK02AG045339 · NIA · UNIVERSITY OF UTAH · PI DONATO, ANTHONY JOHN · 2014 to 2018
$558k
Metabolic implications of adipose arterial function: Role of Robo4 and AMPKI01BX002151 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI LESNIEWSKI, LISA A · 2015 to 2018
–
Role of ARF6 in atherosclerotic burden and severityI01BX004492 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI LESNIEWSKI, LISA A · 2020 to 2023
–
BLRD VA I01 BX002151BLRD VA I01 BX004492NCCIH NIH HHS R00 AT010017NHLBI NIH HHS T32 HL007576NHLBI NIH HHS T32 HL007676NIA NIH HHS K02 AG045339NIA NIH HHS R01 AG048366NIA NIH HHS R01 AG050238NIA NIH HHS R01 AG060395NIA NIH HHS R01 AG077751NIH HHS K02 AG045339NIH HHS R00 AT010017NIH HHS R01 AG048366NIH HHS R01 AG050238NIH HHS R01 AG060395NIH HHS T32HL007576
6 · The paper itself

Abstract

Increased arterial stiffness is a cardiovascular disease risk factor in the setting of advancing age and Western diet (WD) induced obesity. Increases in large artery stiffness, as measured by pulse wave velocity (PWV), occur within 8 weeks of WD feeding in mice. Sirtuin-1 (Sirt1), a NAD-dependent deacetylase, regulates cellular metabolic activity and activation of this protein has been associated with vasoprotection in aged mice. The aim of the study was to elucidate the effect of global Sirt1 overexpression (Sirt

Indexed as

Diet, WesternVascular StiffnessAnimalsAortaCollagenElastinMiceMice, Inbred C57BLPulse Wave AnalysisRNA, MessengerSirtuin 1CollagenElastinRNA, MessengerSirt1 protein, mouseSirtuin 1aortaarterial stiffnessSirt1sirtuinsWestern diet

Identifiers

PMID35561022
PMCPMC9101596
OpenAlexW4280517276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.