ArticleESC heart failure2022
Aberrant static and dynamic functional network connectivity in heart failure with preserved ejection fraction.
Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Multimodal MRI to elucidate cross-organ coupling mechanisms of the heart-brain axis.Frontiers in cardiovascular medicine · 2026Review
- Exploring the bidirectional relationships between MRI resting-state functional connectivity networks and cardiovascular diseases: a Mendelian randomization study.Brain informatics · 2025Article
- Abnormal neural network connectivity in heart failure with reduced and mild-ranged ejection fraction patients: an independent component and dynamic functional network connectivity analysis.Frontiers in neurology · 2025Article
- Aberrant static and dynamic functional network connectivity in heart failure with preserved ejection fraction.ESC heart failure · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHeart failure may lead to brain functional alterations related to cognitive impairment. This study aimed to detect alterations of static functional network connectivity (FNC) and dynamic FNC in heart failure with preserved ejection fraction (HFpEF) and to estimate the association between the altered FNC and clinical features related to HFpEF. METHODS AND
resultsThe clinical and resting-state functional magnetic resonance imaging (fMRI) data of HFpEF patients (n = 35) and healthy controls (HCs) (n = 35) were acquired at baseline. Resting-state networks (RSNs) were established based on independent component analysis (ICA) and FNC analyses were performed. The associations between the FNC abnormalities and clinical features related to HFpEF were analysed. Compared with HCs, HFpEF patients showed decreased functional connectivity within the default mode network, left frontoparietal network, and right frontoparietal network and increased functional connectivity within the right frontoparietal network and visual network. Negative correlations were observed between decreased dynamic FNC and the left ventricular end-diastolic diameter (LVDd) (r = -0.435, P = 0.015) as well as the left ventricular end-systolic diameter (LVDs) (r = -0.443, P = 0.013).
conclusionsThe FNC disruption and altered temporal properties of functional dynamics in HFpEF patients may reflect the neural mechanisms of brain injury after HFpEF, which may deepen our understanding of the disease.
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