Evidence map›Paper›PMID 35559825›Full record

ArticleNanoImpact2021

Transcorneal delivery of topically applied silver nanoparticles does not delay epithelial wound healing.

Soohyun Kim, Brooke L Gates, Maggie Chang, Kent E Pinkerton, Laura Van Winkle, Christopher J Murphy, Brian C Leonard, Philip Demokritou, Sara M Thomasy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NanoImpact, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Soohyun KimDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA.
Brooke L GatesDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA.
Maggie ChangDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA.
Kent E PinkertonCenter for Health and the Environment, University of California, Davis, CA 95616, USA.
Laura Van WinkleCenter for Health and the Environment, University of California, Davis, CA 95616, USA; Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Christopher J MurphyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA; Department of Ophthalmology and Vision Science, School of Medicine, University of California, Davis, CA 95616, USA.
Brian C LeonardDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, HSPH-NIEHS Nanosafety Center, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, 665 Huntington, Boston, MA 02115, USA.
Sara M ThomasyDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California - Davis, Davis, CA 95616, USA; Department of Ophthalmology and Vision Science, School of Medicine, University of California, Davis, CA 95616, USA. Electronic address: smthomasy@ucdavis.edu.
University of California, Davis · USHarvard University · US

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI MARIE E BURNS · 1999 to 2026
$18.9M
Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety ResearchU24ES026946 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2016 to 2020
$3.8M
Biophysical Cues and Corneal Wound HealingR01EY019970 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURPHY, CHRISTOPHER JOHN · 2011 to 2020
$3.5M
Respiratory and Ocular Toxicity of Inhaled NanomaterialsU01ES027288 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED, THOMASY, SARA MICHELLE · 2016 to 2020
$2.2M
Modulation of Hsp90 signaling to limit corneal fibrosis and improve ocular drug penetrationK08EY028199 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD, BRIAN C. · 2017 to 2021
$1.1M
Acquisition of a Cytoviva hyperspectral microscopy systemS10OD021789 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VAN WINKLE, LAURA S · 2017 to 2017
$226k
NEI NIH HHS K08 EY028199NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY019970NIEHS NIH HHS U01 ES027288NIEHS NIH HHS U24 ES026946NIH HHS S10 OD021789
6 · The paper itself

Abstract

Silver nanoparticles (AgNPs) are a common antimicrobial additive for a variety of applications, including wound care. However, AgNPs often undergo dissolution resulting in release of silver ions, with subsequent toxicity to mammalian cells. The cornea is a primary exposure site to topically administered AgNPs in and around the eye but their impact on corneal wound healing is understudied. Thus, the purpose of this study was to determine in vitro toxicity of AgNPs on corneal epithelial cells and fibroblasts as well as their effects on corneal epithelial wound healing utilizing an in vivo rabbit model. Non-coated 20 nm sized AgNP (AgNP-20) as well as 1% and 10% silver silica NPs (AgSiO

Indexed as

Corneal InjuriesMetal NanoparticlesAnimalsMammalsRabbitsRNA, MessengerSilverWound HealingRNA, MessengerSilverCorneal epithelial wound healingKeratocyte-fibroblast-myofibroblast transformationSilver nanoparticlesSilver silica nanoparticlesTranscorneal penetration

Identifiers

PMID35559825
PMCPMC13531338
OpenAlexW3195077348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.