Evidence map›Paper›PMID 35559665›Full record

ArticleScience immunology2022

BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia.

Håvard T Lindholm, Naveen Parmar, Claire Drurey, Marta Campillo Poveda, Pia M Vornewald, Jenny Ostrop, Alberto Díez-Sanchez, Rick M Maizels, Menno J Oudhoff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Håvard T LindholmCEMIR-Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0003-4403-4387
Naveen ParmarCEMIR-Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0002-7535-8846
Claire DrureyWellcome Centre for Integrative Parasitology, Institute of Infection, Immunology and Inflammation, University of Glasgow, G12 8TA Glasgow, UK.ORCID 0000-0002-6001-2527
Marta Campillo PovedaWellcome Centre for Integrative Parasitology, Institute of Infection, Immunology and Inflammation, University of Glasgow, G12 8TA Glasgow, UK.ORCID 0000-0002-2561-5429
Pia M VornewaldCEMIR-Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0003-0810-1538
Jenny OstropCEMIR-Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0003-2752-8377
Alberto Díez-SanchezCEMIR-Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0001-5146-3089
Rick M MaizelsWellcome Centre for Integrative Parasitology, Institute of Infection, Immunology and Inflammation, University of Glasgow, G12 8TA Glasgow, UK.
Menno J OudhoffCEMIR-Centre of Molecular Inflammation Research, Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, 7491 Trondheim, Norway.ORCID 0000-0002-1180-8975
Norwegian University of Science and Technology · NOWellcome Centre for Molecular Parasitology · GB

Funding

Wellcome Trust 104111Wellcome Trust 106122Wellcome Trust 211814Wellcome Trust 219530
6 · The paper itself

Abstract

The intestinal tract is a common site for various types of infections including viruses, bacteria, and helminths, each requiring specific modes of immune defense. The intestinal epithelium has a pivotal role in both immune initiation and effector stages, which are coordinated by lymphocyte cytokines such as IFNγ, IL-13, and IL-22. Here, we studied intestinal epithelial immune responses using organoid image analysis based on a convolutional neural network, transcriptomic analysis, and in vivo infection models. We found that IL-13 and IL-22 both induce genes associated with goblet cells, but the resulting goblet cell phenotypes are dichotomous. Moreover, only IL-13-driven goblet cells are associated with classical NOTCH signaling. We further showed that IL-13 induces the bone morphogenetic protein (BMP) pathway, which acts in a negative feedback loop on immune type 2-driven tuft cell hyperplasia. This is associated with inhibiting

Indexed as

Bone Morphogenetic ProteinsHyperplasiaInterleukin-13Intestinal MucosaFeedbackHumansSOXC Transcription FactorsStrongylida InfectionsBone Morphogenetic ProteinsIL13 protein, humanInterleukin-13SOX4 protein, humanSOXC Transcription Factors

Identifiers

PMID35559665
PMCPMC7614132
OpenAlexW4280571090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.