ArticleAmerican journal of translational research2022
The association of AT-III and D-Dimer with unexplained recurrent spontaneous abortion and their diagnostic value for prethrombotic state.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Correlation Between Serum Markers and Midluteal Phase Doppler Assessment of Uterine Arterial Blood Flow in Unexplained Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Evaluation of platelet parameters, coagulation markers, antiphospholipid syndrome, and thyroid function in palestinian women with recurrent pregnancy loss.BMC pregnancy and childbirth · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the role of antithrombin III (AT-III) and D-dimer (D-Dimer) in patients with unexplained recurrent spontaneous abortion (URSA); Methods: Sixty pregnant women with URSA (AEP group), 80 non-pregnant women with a history of URSA (ANP group), 50 healthy women in early pregnancy (NEP group) and 50 healthy non-pregnant women (NNP group) were retrospectively enrolled. Their serum AT-III and D-Dimer levels were measured. The patients in the ANP group were divided into three subgroups according to the number of miscarriages: 3 miscarriages (32 cases), 4 miscarriages (22 cases), and >4 miscarriages (26 cases), and the differences in serum AT-III and D-Dimer levels among these subgroups were compared. The patients in the AEP group were monitored for changes in AT-III and D-Dimer levels, and finally the diagnostic value of AT-III and D-Dimer levels were calculated for the prethrombotic state of URSA.
results(1) AT-III and D-Dimer levels differed significantly among the 4 groups (P<0.05); (2) As the number of miscarriages increased, D-Dimer levels elevated and AT-III levels decreased, with significant differences among three subgroups (P<0.05); (3) As the treatment proceeded, patients in AEP and ANP groups showed a tendency for a gradual increase in AT-III levels and a significant decrease in D-Dimer levels, with significant differences before and after treatment (P<0.05); (4) The diagnostic AUC of AT-III and D-Dimer in the prediction of prethrombotic state of URSA were 0.8922 (95% CI=0.8026-0.9819, P<0.0001) and 0.8776 (95% CI=0.7643-0.9909, P<0.0001).
conclusionAT-III and D Dimer levels are closely associated with URSA. The results of this study have preliminarily confirmed the feasibility of applying AT-III and D Dimer to screen the prethrombotic state of URSA, and their clinical application will help provide a reference for determining the cause of miscarriage in the infertile population with URSA and facilitate successful pregnancy.
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Identifiers
35559371PMC9091076W4285740620What OpenQuestion holds
Registered trials
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