ArticleFrontiers in medicine2022
Influence of Cardiovascular Risk Burden on Motor Function Among Older Adults: Mediating Role of Cardiovascular Diseases Accumulation and Cognitive Decline.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 40 citations in OpenAlex.
- Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow-Up: Data From the Multicenter Osteoarthritis Study.Arthritis care & research · 2026Article
- Impaired physical function in relation to later-life exposure to ambient fine particulate matter and ozone among Chinese middle-aged and older adults.BMC public health · 2025Article
- Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.Medicine and science in sports and exercise · 2025Article
- Motoric Cognitive Risk Syndrome and Risk of Cardiovascular Disease: A Population-Based Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Arterial calcification in the heart-brain axis and cognitive performance over time.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age.BMC geriatrics · 2024Article
- Cardiovascular risk burden and disability: findings from the International Mobility in Aging Study (IMIAS).Journal of geriatric cardiology : JGC · 2024Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Purpose: This study aimed to investigate the association of the cardiovascular risk burden assessed by the Framingham General Cardiovascular Risk Score (FGCRS) with the trajectories of motor function over time and to assess the mediating effects of cardiovascular diseases (CVDs) accumulation and cognitive decline in such association. Methods: In Rush Memory and Aging Project, a total of 1,378 physical health participants (mean age: 79.3 ± 7.3 years) were followed up for up to 22 years. FGCRS at baseline was assessed and categorized into tertiles (lowest, middle, and highest). Global motor function (including dexterity, gait, and hand strength) was assessed annually with 10 motor tests. CVDs (including stroke, congestive heart failure, and other heart diseases) were ascertained at baseline and follow-ups, and the number of CVDs accumulation over time was assessed. Global cognitive function was tested annually by 19 tests. Data were analyzed using the linear mixed-effects models and mediation analysis. Results: At baseline, FGCRS ranged from 4 to 28 (mean score: 15.6 ± 3.7). Over the follow-up (median: 5.3 years; interquartile range: 2.9-9.0 years), in multi-adjusted mixed-effects models, the highest FGCRS was associated with faster decline in global motor function (β = -0.0038; 95% confidence interval [CI]: -0.0069 to -0.0008), dexterity (β = -0.0056; 95% CI: -0.0093 to -0.0020), gait (β = -0.0039; 95% CI: -0.0077 to -0.0001), and hand strength (β = -0.0053; 95% CI: -0.0098 to -0.0008) compared with the lowest tertile. In mediation analysis, CVDs accumulation and cognitive decline mediated 8.4% and 42.9% of the association between FGCRS and global motor function over time, respectively. Conclusion: Higher cardiovascular risk burden is associated with a faster decline in motor function including dexterity, gait, and hand strength. CVDs accumulation and cognitive decline may partially mediate the association between cardiovascular risk burden and global motor function decline.
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