Evidence map›Paper›PMID 35559296›Full record

ArticleRSC advances2018

Design and characterization of chionodracine-derived antimicrobial peptides with enhanced activity against drug-resistant human pathogens.

Cristina Olivieri, Francesca Bugli, Giulia Menchinelli, Gianluigi Veglia, Francesco Buonocore, Giuseppe Scapigliati, Valentina Stocchi, Francesca Ceccacci, Massimiliano Papi, Maurizio Sanguinetti and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  8. Article
  9. Article
  10. Review
  11. Review
  12. Emerging Strategies to Combat β-Lactamase Producing ESKAPE Pathogens.International journal of molecular sciences · 2020
    Review
  13. Article
  14. Article
  15. Intrinsically disordered HAX-1 regulates CaBiochimica et biophysica acta. Biomembranes · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cristina OlivieriDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia L.go dell'Universita' snc 01100 Viterbo Italy porcelli@unitus.it +390761357041.
Francesca BugliMicrobiology Institute, Catholic University of Sacred Heart Rome Italy maurizio.sanguinetti@unicatt.it.
Giulia MenchinelliMicrobiology Institute, Catholic University of Sacred Heart Rome Italy maurizio.sanguinetti@unicatt.it.
Gianluigi VegliaDepartment of Chemistry, University of Minnesota Minneapolis 55455 USA.
Francesco BuonocoreDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia L.go dell'Universita' snc 01100 Viterbo Italy porcelli@unitus.it +390761357041.ORCID https://orcid.org/0000-0001-8045-5651
Giuseppe ScapigliatiDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia L.go dell'Universita' snc 01100 Viterbo Italy porcelli@unitus.it +390761357041.
Valentina StocchiDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia L.go dell'Universita' snc 01100 Viterbo Italy porcelli@unitus.it +390761357041.
Francesca CeccacciCNR - Institute of Chemical Methodologies, Sezione Meccanismi di Reazione UOS of Rome Rome Italy.
Massimiliano PapiPhysics Institute, Catholic University of Sacred Heart Rome Italy.
Maurizio SanguinettiMicrobiology Institute, Catholic University of Sacred Heart Rome Italy maurizio.sanguinetti@unicatt.it.
Fernando PorcelliDepartment for Innovation in Biological, Agrofood and Forest Systems, University of Tuscia L.go dell'Universita' snc 01100 Viterbo Italy porcelli@unitus.it +390761357041.ORCID https://orcid.org/0000-0003-3209-0074

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starting from the sequence of the amphipathic α-helix of chionodracine (Cnd, 22 amino acids), we designed a series of mutants to increase Cnd's antimicrobial activity and selectivity toward prokaryotic cells and drug-resistant bacterial pathogens. We characterized these new Cnd-derived peptides using fluorescence, CD spectroscopy, and transmission electron microscopy, studying their interactions with synthetic lipid vesicles and assaying their biological function against

Identifiers

PMID35559296
PMCPMC9091591

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.