ArticleTranslational pediatrics2022
Risk factors of cerebral palsy in children: a systematic review and meta-analysis.
Article in Translational pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Born at higher risk: persistent male excess risk of cerebral palsy from extreme prematurity to term: a systematic review and meta-analysis.Biology of sex differences · 2026Pooled it
- Global prevalence of developmental disabilities in children and adolescents: A systematic umbrella review.Frontiers in public health · 2023Pooled it
- Early cerebral palsy risk screening through wearable accelerometry in infants under nine weeks.Scientific reports · 2026Article
- Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy.Nature communications · 2025Article
- Narrative review of neurodevelopmental and psychiatric complications associated with prematurity.BMC pediatrics · 2025Review
- A Study on Hemodynamic and Brain Network Characteristics During Upper Limb Movement in Children with Cerebral Hemiplegia Based on fNIRS.Brain sciences · 2025Article
- Metabolomics analysis of children with spastic cerebral palsy: a case-control study.BMC pediatrics · 2025Article
- Impact of assisted reproductive technology on the risk of cerebral palsy: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Inflammatory Markers in the Blood of Spastic Cerebral Palsy Children: A Case-Control Study.Children (Basel, Switzerland) · 2025Article
- Early-onset preeclampsia/gestational hypertension may be associated with a low incidence of cerebral palsy at 3 years old in singleton very low-birth-weight infants born at 28-31 weeks of gestation (EOPE-DQ study): a multi-center retrospective cohort study in 2013-2016.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Preterm Birth as a Risk Factor for Cerebral Palsy in Children: A Systematic Review and Meta-Analysis.Neurology research international · 2025Review
- Long-term health outcomes of preterm birth: a narrative review.Frontiers in pediatrics · 2025Review
- Short-Term and Long-Term Mortality Risk After Preterm Birth.JAMA network open · 2024Article
- Employing Siamese Networks as Quantitative Biomarker for Assessing the Effect of Dolphin-Assisted Therapy on Pediatric Cerebral Palsy.Brain sciences · 2024Article
- Long-term outcomes of very low birth weight infants with intraventricular hemorrhage: a nationwide population study from 2011 to 2019.World journal of pediatrics : WJP · 2024Article
- Randomized controlled trial comparing the impacts ofTranslational pediatrics · 2024Article
- Determinants of cerebral palsy in children: systematic review.Sudanese journal of paediatrics · 2023Review
- Review on Prevention of Cerebral Palsy from the Perspective of Social Pediatrics.Turkish archives of pediatrics · 2022Article
- Predicting the brain age of children with cerebral palsy using a two-dimensional convolutional neural networks prediction model without gray and white matter segmentation.Frontiers in neurology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aimed to explore the main risk factors for cerebral palsy in children by meta-analysis of the literature on the risk factors of cerebral palsy. Methods: We performed a literature search of the PubMed, EMBASE, Medline, and CENTRAL databases using the following search terms: ("cerebrl plsy" or "cerebrl plsis" or "infantile cerebral palsy") and ("risk factors"). Case-control or cohort studies of children with cerebral palsy and healthy children were included for meta-analysis. The Newcastle-Ottawa Scale (NOS) of case-control studies was used to evaluate the quality of the included studies. The Chi-square test was used to test the heterogeneity of the literature. This study used subgroup analysis and sensitivity analysis to identify sources of heterogeneity. If subgroup analyses and sensitivity analyses could not identify the source of heterogeneity, no pooling between study results was performed, and only individual study results were described. In this study, Egger's test was used to test for publication bias. The random-effects model was used when heterogeneity existed, and the fixed-effect model was applied when heterogeneity did not exist. Results: A total of 1,836 related articles were retrieved. After screening, 13 articles were included in the analysis, involving a total of 2,489 children with cerebral palsy and 4,782 children without cerebral palsy. None of the included articles achieved a NOS score of 9, four articles scored 8, eight articles scored 7, and one article scored 6. Meta-analysis showed that maternal hypertension during pregnancy, premature rupture of membranes, premature delivery and emergency cesarean section were risk factors for cerebral palsy in children, and there was no heterogeneity among the literatures and no publication bias. Conclusions: This study identified gestational hypertension, preterm birth, premature rupture of membranes, and emergency cesarean section as risk factors for cerebral palsy in children through meta-analysis, providing a reference for risk monitoring and clinical intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.