Evidence map›Paper›PMID 35558874›Full record

ArticleFrontiers in cellular neuroscience2022

The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons.

Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang, Seog Bae Oh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

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  11. Modulation ofInternational journal of molecular sciences · 2025
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  15. Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Hiroki ToyodaDepartment of Neuroscience and Oral Physiology, Graduate School of Dentistry, Osaka University, Suita, Japan.
Jonghwa WonDepartment of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Wheedong KimDepartment of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Hayun KimInterdisciplinary Program for Brain Science, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Oscar DavySchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.
Mitsuru SaitoDepartment of Oral Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Doyun KimDepartment of Neurobiology and Physiology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, South Korea.
Takuma TanakaGraduate School of Data Science, Shiga University, Hikone, Japan.
Youngnam KangDepartment of Neuroscience and Oral Physiology, Graduate School of Dentistry, Osaka University, Suita, Japan.
Seog Bae OhDepartment of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
Seoul National University Dental Hospital · KRSeoul National University · KRKagoshima University · JPShiga University · JPThe University of Osaka · JPUniversity of Bristol · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noradrenergic neurons in the locus coeruleus (LC) release noradrenaline (NA) that acts

Indexed as

HCN channellocus coeruleusmesencephalic trigeminal nucleus neuronsvolume transmissionα2A-adrenergic receptor

Identifiers

PMID35558874
PMCPMC9087804
OpenAlexW4224868063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.