Evidence map›Paper›PMID 35558840›Full record

ArticleRSC advances2022

An innovative electrochemical immuno-platform towards ultra-sensitive monitoring of 2-arachidonoyl glycerol in samples from rats with sleep deprivation: bioanalysis of endogenous cannabinoids using biosensor technology.

Fereshteh Kohansal, Ahmad Mobed, Rana Ansari, Mohammad Hasanzadeh, Ali Ahmadalipour, Nasrin Shadjou

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fereshteh KohansalPharmaceutical Analysis Research Center, Tabriz University of Medical Sciences Tabriz 51664 Iran hasanzadehm@tbzmed.ac.ir.
Ahmad MobedAging Research Institute, Faculty of Medicine, Tabriz University of Medical Sciences Iran.ORCID https://orcid.org/0000-0001-8939-3688
Rana AnsariDrug Applied Research Center, Tabriz University of Medical Sciences Iran.
Mohammad HasanzadehPharmaceutical Analysis Research Center, Tabriz University of Medical Sciences Tabriz 51664 Iran hasanzadehm@tbzmed.ac.ir.ORCID https://orcid.org/0000-0003-4918-1239
Ali AhmadalipourResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences Iran ali.ahmadalipour1@gmail.com.
Nasrin ShadjouDepartment of Nanochemistry, Nanotechnology Research Center, Faculty of Science and Chemistry, Urmia University Urmia Iran.ORCID https://orcid.org/0000-0001-5961-3686
Tabriz University of Medical Sciences · IRUrmia University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endocannabinoid system (ECS) is a complex of neurotransmitters in the central nervous system and plays a key role in regulating cognitive and physiological processes. 2-Arachidonoylglycerol (2-AG) is one of the imperative endocannabinoids that play key roles in the central nervous system. It acts as a signaling lipid and activates the cannabinoid CB1 receptor. In addition, 2-AG is involved in a variety of physiological functions such as energy balance, emotion, pain sensation, cognition, and neuroinflammation. So, rapid and specific diagnosis of 2-AG is of great importance in medical neuroscience. The development of new methods in this area has been one of the most important research areas in recent years. Herein, an innovative immunosensor is developed for quantification of 2-AG. For this means, gold nanostars (GNS) were synthesized and conjugated with a specific biotinylated antibody against 2-AG. The resultant bioconjugate, a bioreceptor with GNS, was immobilized on the surface of a gold electrode and used for the detection of the antigen based on the immunocomplex formation followed by analysis using different electrochemical techniques. For the first time, 2-AG protein was measured with an excellent linear range of 0.48-1 ng mL

Identifiers

PMID35558840
PMCPMC9092357
OpenAlexW4280565478

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.