Evidence map›Paper›PMID 35558765›Full record

ArticleRSC advances2018

Eccentric magnetic microcapsules for MRI-guided local administration and pH-regulated drug release.

Jingxian Huang, Wenwei Huang, Yin Chen, Yu Shrike Zhang, Jinshuang Zhong, Yan Li, Jianhua Zhou

Abstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingxian HuangSchool of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China chenyin8@mail.sysu.edu.cn zhoujh33@mail.sysu.edu.cn +86 20 39387890 +86 20 39387890.
Wenwei HuangSchool of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China chenyin8@mail.sysu.edu.cn zhoujh33@mail.sysu.edu.cn +86 20 39387890 +86 20 39387890.ORCID https://orcid.org/0000-0002-7756-6577
Yin ChenSchool of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China chenyin8@mail.sysu.edu.cn zhoujh33@mail.sysu.edu.cn +86 20 39387890 +86 20 39387890.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School 65 Landsdowne Street Cambridge Massachusetts 02139 USA.ORCID https://orcid.org/0000-0002-0045-0808
Jinshuang ZhongSchool of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China chenyin8@mail.sysu.edu.cn zhoujh33@mail.sysu.edu.cn +86 20 39387890 +86 20 39387890.
Yan LiSchool of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China chenyin8@mail.sysu.edu.cn zhoujh33@mail.sysu.edu.cn +86 20 39387890 +86 20 39387890.ORCID https://orcid.org/0000-0003-3115-8380
Jianhua ZhouSchool of Biomedical Engineering, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510006 China chenyin8@mail.sysu.edu.cn zhoujh33@mail.sysu.edu.cn +86 20 39387890 +86 20 39387890.ORCID https://orcid.org/0000-0001-9895-8679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we present a novel class of uniform eccentric magnetic microcapsules based on polydimethylsiloxane (PDMS) for magnetic resonance imaging (MRI)-guided local injection and pH-regulated drug release. The microcapsules contained magnetic nanoparticles in their PDMS shells, which allowed them to be easily tracked by MRI during administration. Besides, they showed pH-dependent drug release profiles due to dissolution of the embedded magnetic nanoparticles in acidic solutions. Moreover, by tuning the mass fraction of the magnetic nanoparticles, we could further regulate the release rate of drug molecules from them. As a demonstration, we investigated the delivery of cis-platinum using the microcapsules through an

Identifiers

PMID35558765
PMCPMC9092120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.