Evidence map›Paper›PMID 35558748›Full record

ArticleFrontiers in nutrition2022

Association Between Skeletal Muscle Mass and Severity of Steatosis and Fibrosis in Non-alcoholic Fatty Liver Disease.

Wen Guo, Xin Zhao, Mengyuan Miao, Xiuru Liang, Xiaona Li, Pei Qin, Jing Lu, Wenfang Zhu, Juan Wu, Chen Zhu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  12. Impact of segmental body composition on metabolicFrontiers in endocrinology · 2025
    Article
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  15. Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease.World journal of gastrointestinal pathophysiology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Wen GuoDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xin ZhaoDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Mengyuan MiaoDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xiuru LiangDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xiaona LiDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Pei QinDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Jing LuDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Wenfang ZhuDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Juan WuDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Chen ZhuDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Nianzhen XuDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Qun ZhangDepartment of Health Promotion Center, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcopenia is known to be the risk factor of non-alcoholic fatty liver disease (NAFLD). However, studies evaluating the association of skeletal muscle mass (SMM) with liver fibrosis by transient elastography are limited. Here, we investigated the association of SMM with hepatic steatosis and fibrosis assessed in Chinese adults. Methods: Patients who underwent liver ultrasonography at the Health Promotion Center of the First Affiliated Hospital of Nanjing Medical University between January 2020 to June 2021 were enrolled. We used transient elastography to evaluate the degree of hepatic fat and liver stiffness. Appendicular skeletal muscle mass was determined by bioelectrical impedance and was adjusted for body weight to derive the skeletal muscle mass index (SMI). Results: Of 3,602 finally enrolled individuals, 1,830 had NAFLD and 1,772 did not have NAFLD. SMI gradually decreased as the severity of hepatic steatosis increased (40.47 ± 3.94% vs. 39.89 ± 3.57% vs. 39.22 ± 3.46% vs. 37.81 ± 2.84%, Conclusion: SMI is closely associated with liver fat content and liver fibrosis in Chinese adults with NAFLD.

Indexed as

hepatic steatosisliver fibrosisnon-alcoholic fatty liver diseaseskeletal muscle massskeletal muscle mass index

Identifiers

PMID35558748
PMCPMC9087584
OpenAlexW4224988105

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.