ArticleRSC advances2018
The effect of a single injection of uniform-sized insulin-loaded PLGA microspheres on peri-implant bone formation.
Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- PLGA Implants for Controlled Drug Delivery and Regenerative Medicine: Advances, Challenges, and Clinical Potential.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Deep Neural Networks Based on Sp7 Protein Sequence Prediction in Peri-Implant Bone Formation.International journal of dentistry · 2025Article
- The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment.Pharmaceutics · 2024Review
- Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication.AAPS PharmSciTech · 2023Article
- Effects of alendronate combined with local radiotherapy on serum Akt/GSK3β and bone metabolism levels in patients with bone metastases from primary liver cancer.American journal of translational research · 2022Article
- Biodegradable Polymers as Drug Delivery Systems for Bone Regeneration.Pharmaceutics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium implants are widely used treatment modalities, with a long list of clinical successes in orthopaedics, orthopedics and maxillofacial surgery. However, early implant loss occurs in 4.4% of patients, and to overcome this issue, bioactive factors have been generally used for improving peri-implant bone formation. Recently, the role of insulin in the improvement of bone development and physiology has attracted considerable attention. Nevertheless, one injection of insulin could not have a persistent effect in the site for bone formation because of its fast metabolism and instability, leading to limited efficacy. Moreover, the wider size distribution of microspheres frequently leads to uncontrollable insulin release, which affects preparation repeatability, drug efficacy and reliability. Herein, we developed uniform-sized insulin-loaded poly(dl-lactic-
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.