Evidence map›Paper›PMID 35558102›Full record

ArticleFrontiers in cellular and infection microbiology2022

Uremic Toxin-Producing

Subhashree Shivani, Cheng-Yen Kao, Amrita Chattopadhyay, Jenn-Wei Chen, Liang-Chuan Lai, Wei-Hung Lin, Tzu-Pin Lu, I-Hsiu Huang, Mong-Hsun Tsai, Ching-Hao Teng and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Subhashree ShivaniGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
Cheng-Yen KaoInstitute of Microbiology and Immunology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Amrita ChattopadhyayCenter for Translational Genomic Research, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Jenn-Wei ChenDepartment of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Liang-Chuan LaiGraduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wei-Hung LinDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tzu-Pin LuBioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan.
I-Hsiu HuangDepartment of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, United States.
Mong-Hsun TsaiBioinformatics and Biostatistics Core, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan.
Ching-Hao TengInstitute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Jiunn-Jong WuDepartment of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Yi-Hsien HsiehDepartment of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Ming-Cheng WangDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Eric Y ChuangGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
National Taiwan University · TWNational Cheng Kung University · TWNational Cheng Kung University Hospital · TWNational Yang Ming Chiao Tung University · TWChina Medical University Hospital · TWChung Shan Medical University · TWOklahoma State University Center for Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale and Objective: Gut microbiota have been targeted by alternative therapies for non-communicable diseases. We examined the gut microbiota of a healthy Taiwanese population, identified various bacterial drivers in different demographics, and compared them with dialysis patients to associate kidney disease progression with changes in gut microbiota. Study Design: This was a cross-sectional cohort study. Settings and Participants: Fecal samples were obtained from 119 healthy Taiwanese volunteers, and 16S rRNA sequencing was done on the V3-V4 regions to identify the bacterial enterotypes. Twenty-six samples from the above cohort were compared with fecal samples from 22 peritoneal dialysis and 16 hemodialysis patients to identify species-level bacterial biomarkers in the dysbiotic gut of chronic kidney disease (CKD) patients. Results: Specific bacterial species were identified pertaining to different demographics such as gender, age, BMI, physical activity, and sleeping habits. Dialysis patients had a significant difference in gut microbiome composition compared to healthy controls. The most abundant genus identified in CKD patients was Conclusion: This study characterizes the healthy gut microbiome of a Taiwanese population in terms of various demographics. In a case-control examination, the results showed the alteration in gut microbiota in CKD patients corresponding to different dialysis treatments. Also, this study identified the bacterial species abundant in CKD patients and their possible role in complicating the patients' condition.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaRenal Insufficiency, ChronicToxins, BiologicalBacteriaBacteroidesCross-Sectional StudiesDysbiosisFemaleHumansMaleRNA, Ribosomal, 16STaiwanUremic ToxinsRNA, Ribosomal, 16SToxins, BiologicalUremic Toxinschronic kidney diseasedysbiosisgut microbiotahemodialysisperitoneal dialysisTaiwanuremic toxin

Identifiers

PMID35558102
PMCPMC9086402
OpenAlexW4224861929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.