ArticleRegenerative biomaterials2022
Utilizing 3D bioprinted platelet-rich fibrin-based materials to promote the regeneration of oral soft tissue.
Article in Regenerative biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Bio-inks with PRF Increase Human Osteosarcoma Cell Line (SaOS-2) Viability in Extrusion-Based 3D-Bioprinted Constructs.Annals of biomedical engineering · 2026Article
- Shelf-Stable, Rapid-Gelling, and Robust Thrombin-Independent Fibrinogen-Based Hydrogels for Massive Hemorrhage Control.Advanced healthcare materials · 2026Article
- Fibrin-Based Biomaterials in Wound Healing and Soft Tissue Regeneration: Biological Mechanisms and Clinical Applications.Gels (Basel, Switzerland) · 2026Review
- Material-dependent effects of injectable platelet rich-fibrin on growth factor release, inflammation, and osteoclast activity: an in vitro study.BMC oral health · 2026Article
- Biofabrication for complex tissue regeneration: a scoping review of translational gaps in craniomaxillofacial reconstruction.Frontiers in oral health · 2026Review
- Advanced biomaterial-based approaches for medication-related osteonecrosis of the jaw.Open life sciences · 2026Article
- Advances in 3D Printed Scaffolds for Periodontal Regeneration.Current oral health reports · 2026Review
- IGFBP3 enhances adipose-derived stem cell function in soft tissue injury repair via ITGB1 and ERK pathway activation.Cell biology and toxicology · 2025Article
- The Properties and Applicability of Bioprinting in the Field of Maxillofacial Surgery.Bioengineering (Basel, Switzerland) · 2025Review
- Advances in Fibrin-Based Bioprinting for Skin Tissue Regeneration: Exploring Design, and Innovative Approaches.Biomedical materials & devices (New York, N.Y.) · 2025Article
- Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review.Materials today. Bio · 2024Review
- Autologous platelet-rich fibrin enhances skin wound healing in a feline trauma model.BMC veterinary research · 2024Article
- Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three-Dimensional Bioprinting.International journal of molecular sciences · 2024Review
- 3D Bioprinting Techniques and Bioinks for Periodontal Tissues Regeneration-A Literature Review.Biomimetics (Basel, Switzerland) · 2024Review
- Advances in hybridized nanoarchitectures for improved oro-dental health.Journal of nanobiotechnology · 2024Review
- Advances in functional coatings on biliary stents.Regenerative biomaterials · 2024Review
- Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate.Frontiers in bioengineering and biotechnology · 2024Article
- 3D printing sequentially strengthening high-strength natural polymer hydrogel bilayer scaffold for cornea regeneration.Regenerative biomaterials · 2024Article
- Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2024Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral soft tissue defects remain difficult to treat owing to the limited efficacy of available treatment materials. Although the injectable platelet-rich fibrin (i-PRF) is a safe, autologous source of high levels of growth factors that is often employed to promote the regeneration of oral soft tissue, its effectiveness is restrained by difficulties in intraoperative shaping together with the burst-like release of growth factors. We herein sought to develop a bioactive bioink composed of i-PRF, alginate and gelatin capable of promoting the regeneration of the oral soft tissue. This bioink was successfully applied in 3D bioprinting and exhibited its ability to be shaped to individual patient needs. Importantly, we were also able to significantly prolong the duration of multiple growth factors release as compared to that observed for i-PRF. The growth factor bioavailability was further confirmed by the enhanced proliferation and viability of printed gingival fibroblasts. When deployed
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Registered trials
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