Evidence map›Paper›PMID 35558066›Full record

ArticleFrontiers in immunology2022

Case Report: Invasive Cryptococcosis in French Guiana: Immune and Genetic Investigation in Six Non-HIV Patients.

Jeanne Goupil de Bouillé, Loïc Epelboin, Fanny Henaff, Mélanie Migaud, Philippe Abboud, Denis Blanchet, Christine Aznar, Felix Djossou, Olivier Lortholary, Narcisse Elenga and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Neurological Sequelae After Paediatric Cryptococcal Meningitis.Journal of fungi (Basel, Switzerland) · 2025
    Review
  2. Human immunity to fungal infections.The Journal of experimental medicine · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Jeanne Goupil de BouilléAvicenne Hospital, Assistance Publique des Hôpitaux de Paris, Bobigny, France.
Loïc EpelboinCayenne Hospital, Cayenne, French Guiana.
Fanny HenaffCayenne Hospital, Cayenne, French Guiana.
Mélanie MigaudImagine Institute, Paris Cité University, Paris, France.
Philippe AbboudCayenne Hospital, Cayenne, French Guiana.
Denis BlanchetCayenne Hospital, Cayenne, French Guiana.
Christine AznarCayenne Hospital, Cayenne, French Guiana.
Felix DjossouCayenne Hospital, Cayenne, French Guiana.
Olivier LortholaryLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut national de la santé et de la recherche médicale U1163, Necker Hospital, Assitance Publique des hôpitaux de Paris (APHP), Paris, France.
Narcisse ElengaCayenne Hospital, Cayenne, French Guiana.
Anne PuelImagine Institute, Paris Cité University, Paris, France.
Fanny LanternierImagine Institute, Paris Cité University, Paris, France.
Magalie DemarCayenne Hospital, Cayenne, French Guiana.
University of French Guiana · GFAssistance Publique – Hôpitaux de Paris · FRInstitut des Maladies Génétiques Imagine · FRUniversité Sorbonne Paris Nord · FR

Funding

Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasisR01AI127564 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Anne Puel · 2017 to 2026
$4.8M
NIAID NIH HHS R01 AI127564
6 · The paper itself

Abstract

Objectives: We describe the clinical, mycological, immunological, and genetic characteristics of six HIV-negative patients presenting with invasive cryptococcosis. Methods: Patients with cryptococcosis without any of the classical risk factors, such as HIV infection, followed at Cayenne Hospital, were prospectively included. An immunologic and genetic assessment was performed. Results: Five male patients and one female patient, 5 adults and one child, were investigated. All presented a neuromeningeal localization. Conclusion: To better understand cryptococcosis in patients with cryptococcosis but otherwise healthy, further explorations are needed with repeated immune checkups and strain virulence studies.

Indexed as

CryptococcosisCryptococcus gattiiCryptococcus neoformansHIV InfectionsAdultAutoantibodiesChildFemaleFrench GuianaHumansMaleAutoantibodiesantibodies against IFN-γautoantibodies against GM-CSFcryptococcosisfungal infectionimmunocompetentSTAT1 gene

Identifiers

PMID35558066
PMCPMC9088011
OpenAlexW4225014377

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.