ArticleFrontiers in aging neuroscience2022
Decreased Vessel Density in Retinal Capillary Plexus and Thinner Ganglion Cell Complex Associated With Cognitive Impairment.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- A Systematic Review on Retinal Biomarkers to Diagnose Dementia from OCT/OCTA Images.Journal of Alzheimer's disease reports · 2023Pooled it
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Retinal microvascular density and inner thickness in Alzheimer's disease and mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Retinal OCT biomarkers and their association with cognitive function-clinical and AI approaches.Die Ophthalmologie · 2025Article
- Decreased retinal vascular density is associated with cognitive impairment in CADASIL: an optical coherence tomography angiography study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- [Retinal optical coherence tomography biomarkers and their association with cognitive functions : Clinical and artificial intelligence approaches. German version].Die Ophthalmologie · 2024Review
- Relationship of retinal capillary plexus and ganglion cell complex with mild cognitive impairment and dementia.Eye (London, England) · 2023Article
- The Eye as a Diagnostic Tool for Alzheimer's Disease.Life (Basel, Switzerland) · 2023Review
- Retinal microvasculature and incident dementia over 10 years: The Three-City-Alienor cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Cognitive function correlates with retinal structural and vascular imaging parameters in Chinese older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To determine the association of the retinal capillary plexus (RCP) and ganglion cell complex (GCC) with cognitive impairment using optical coherence tomography angiography (OCTA). Methods: A cross-sectional, community-based study utilizing data from the participants enrolled between August 2019 and January 2020 in the Jidong Eye Cohort Study. We assessed the vessel density in RCP and GCC thickness using OCTA, and cognitive testing using the Montreal Cognitive Assessment (MoCA). Cognitive impairment in this study was defined as MoCA score < 24. We used multivariable analysis to evaluate the association of RCP and GCC with cognitive impairment after adjusting for confounders. Results: This study analyzed 1555 participants. The mean age of participants was 52.3 (8.4) years, and 861 (55.4%) were women. Cognitive impairment was observed in 268 (17.2%) participants. The adjusted odds ratio (OR) with 95% confidence interval (95% CI) for parafovea vessel density in the deep RCP with cognitive impairment was 1.20 (1.03-1.39). For vessel area and length density surrounding foveal avascular zone with cognitive impairment, the ORs with 95% CIs were 1.23 (1.07-1.41) and 1.30 (1.13-1.49), respectively. For thickness in the superior GCC with cognitive impairment, the OR with 95% CI was 1.16 (1.01-1.32). Conclusion: Lower vessel density in the RCP and thinner GCC were associated with cognitive impairment. Our results suggest that alterations in the RCP and GCC could provide further evidence when assessing the cognitive function and may even be potentially useful biomarkers in the detection of cognitive impairment.
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