Evidence map›Paper›PMID 35557780›Full record

ArticleRSC advances2018

An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations.

Huan He, Li Li, Libo Zhao, Ning Sun, Meng Zhang, Ying Cheng, Lu Yu, Lin Ma, Xiaoling Wang

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Huan HeClinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China eyjdb6380@163.com.
Li LiDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China bch_maleen@aliyun.com.
Libo ZhaoClinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China eyjdb6380@163.com.
Ning SunClinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China eyjdb6380@163.com.
Meng ZhangClinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China eyjdb6380@163.com.
Ying ChengDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China bch_maleen@aliyun.com.
Lu YuDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China bch_maleen@aliyun.com.
Lin MaDepartment of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China bch_maleen@aliyun.com.
Xiaoling WangClinical Research Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health Beijing 100045 China eyjdb6380@163.com.ORCID https://orcid.org/0000-0002-8930-1197
Capital University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propranolol is now a preferred treatment for infantile hemangioma. However, there are no published papers on the metabolism and concentrations of propranolol in the plasma of infants with hemangioma. In the present study, a sensitive, simple and reliable method was developed and validated for the simultaneous quantification of propranolol and its metabolites 4-hydroxypropranolol (M1) and

Identifiers

PMID35557780
PMCPMC9089243
OpenAlexW2899573178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.