Evidence map›Paper›PMID 35557759›Full record

ArticleJACS Au2022

Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo.

Julia Ast, Alissa N Novak, Tom Podewin, Nicholas H F Fine, Ben Jones, Alejandra Tomas, Ramona Birke, Kilian Roßmann, Bettina Mathes, Jenny Eichhorst and 4 more

Abstract read
In one paragraph

Article in JACS Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. GLP-1 activates KNature communications · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Chemical science · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julia AstInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0002-0039-4762
Alissa N NovakDepartment of Pediatrics, and Indiana Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Tom PodewinDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Nicholas H F FineInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0003-2343-8534
Ben JonesSection of Endocrinology and Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London W12 0NN, U.K.ORCID https://orcid.org/0000-0003-0461-2584
Alejandra TomasSection of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London W12 0NN, U.K.ORCID https://orcid.org/0000-0002-2290-8453
Ramona BirkeLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.
Kilian RoßmannLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.
Bettina MathesDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.
Jenny EichhorstDepartment of Pharmacology and Cell Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.
Martin LehmannDepartment of Pharmacology and Cell Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.ORCID https://orcid.org/0000-0002-8370-6353
Amelia K LinnemannDepartment of Pediatrics, and Indiana Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID https://orcid.org/0000-0001-7356-4876
David J HodsonInstitute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0002-8641-8568
Johannes BroichhagenDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg 69120, Germany.ORCID https://orcid.org/0000-0003-3084-6595

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).U24DK104162 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI John S. Kaddis, Joyce Carol Niland · 2019 to 2026
$12.3M
Human Islet Research Network (HIRN) Coordinating CenterU01DK104162 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI NILAND, JOYCE CAROL · 2014 to 2018
$6.1M
Autophagy/antioxidant response coupling in pancreatic beta-cell homeostasis regulationR01DK124380 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI LINNEMANN, AMELIA K · 2021 to 2025
$2.0M
Confocal/multiphoton microscope system for the Indiana Center for Biological MicroscopyS10OD025136 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI DUNN, KENNETH W · 2019 to 2019
$599k
Mechanisms of IL-6 Signaling in Beta-cell Stress ResponseR03DK115990 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI LINNEMANN, AMELIA K · 2018 to 2019
$236k
Medical Research Council MR/K023667/1Medical Research Council MR/N00275X/1Medical Research Council MR/R010676/1Medical Research Council MR/S025618/1NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK124380NIDDK NIH HHS R03 DK115990NIDDK NIH HHS U01 DK104162NIDDK NIH HHS U24 DK104162NIH HHS S10 OD025136
6 · The paper itself

Abstract

The glucagon-like peptide-1 receptor (GLP1R) is expressed in peripheral tissues and the brain, where it exerts pleiotropic actions on metabolic and inflammatory processes. Detection and visualization of GLP1R remains challenging, partly due to a lack of validated reagents. Previously, we generated

Identifiers

PMID35557759
PMCPMC9088800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.