Evidence map›Paper›PMID 35557748›Full record

ArticleRSC advances2019

LncRNA ZEB1-AS1 inhibits renal fibrosis in diabetic nephropathy by regulating the miR-217/MAFB axis.

Yan Song, Chunxia Miao, Jianwen Wang

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yan SongDepartment of Nephrology, People's Hospital of Rizhao No. 126, Taian Road Rizhao Shandong 276800 China yilonghanjnpvy@163.com +86 0633 3365610.
Chunxia MiaoDepartment of Nephrology, People's Hospital of Rizhao No. 126, Taian Road Rizhao Shandong 276800 China yilonghanjnpvy@163.com +86 0633 3365610.
Jianwen WangDepartment of Nephrology, People's Hospital of Rizhao No. 126, Taian Road Rizhao Shandong 276800 China yilonghanjnpvy@163.com +86 0633 3365610.ORCID https://orcid.org/0000-0003-0117-7484
People’s Hospital of Rizhao · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) is a common chronic microvascular complication of diabetes, characterized by the deposition of extracellular matrix (ECM) proteins. Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) has been implicated in kidney fibrosis of human DN. Here, we further explored the detailed molecular mechanism of ZEB1-AS1 in renal fibrosis in DN. The expression of ZEB1-AS1 was monitored using a quantitative real-time polymerase chain reaction. Blood glucose concentrations of mice were measured using a fast blood glucose meter. The high-performance liquid chromatography method was used to measure the serum creatinine level. Western blot analysis was used to detect the protein level of α-smooth muscle actin (α-SMA), fibronectin, collagen I, collagen IV and MAFB. The level of urine albumin was detected using the BCG (Bromocresol Green) albumin assay kit. The interaction between ZEB1-AS1, miR-217 and MAFB was investigated

Identifiers

PMID35557748
PMCPMC9088285
OpenAlexW2976656340

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.