Evidence map›Paper›PMID 35557573›Full record

ArticleJournal of gastrointestinal oncology2022

A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma.

Sina Cai, Yuqin Zhang, Xiaona Zhang, Liping Wang, Ziqing Wu, Weiyi Fang, Xiaohua Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Sina Cai *Department of Oncology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yuqin Zhang *Department of Clinical Oncology, The Affiliated Chenzhou Hospital, Hengyang Medical School, University of South China, Chenzhou, China.
Xiaona Zhang *Graceland Medical Center, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Liping WangDepartment of Clinical Oncology, South University of Science and Technology Hospital, Shenzhen, China.
Ziqing WuCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Weiyi FangCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Xiaohua ChenCancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
TCM-Intigrated Cancer Center of Southern Medical University · CNPanyu District Central Hospital · CNSouthern University of Science and Technology · CNSun Yat-sen University · CNThird Affiliated Hospital of Southern Medical University · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recent studies indicate that non-coding circular RNAs (circRNAs) are involved in the development of esophageal carcinoma (EC). This study aimed to identify differential expression of circRNAs in EC, which can provide potential biomarkers and therapeutic targets for EC treatment and improve the understanding of tumorigenesis mechanism. Methods: First, samples (n=5) of EC tissues and adjacent normal tissue were sent for circRNA microarray detection, Second, further bioinformatic analysis was performed, including circRNA-microRNA (miRNA), co-expression network analysis, Spearman correlation test, and cancer-related circRNA-miRNA axis analysis. Finally, the expression of circRNA that our analysis predicted to be hub genes was verified in samples (n=15) of EC tissues and adjacent normal tissue by real-time polymerase chain reaction (RT-PCR). Results: Microarray identified 102 upregulated and 67 significantly downregulated circRNAs were in EC patients' tumors relative to adjacent normal tissue. One upregulated circRNA ( Conclusions: Abnormal expression of circRNAs was involved in the tumorigenesis of EC. Key circRNAs, namely

Indexed as

bioinformatic analysiscircular RNAs (circRNAs)Esophageal carcinoma (EC)microarraymicroRNA sponge

Identifiers

PMID35557573
PMCPMC9086029
OpenAlexW4280585588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.