Evidence map›Paper›PMID 35556218›Full record

ArticleJournal of molecular neuroscience : MN2022

Octadecaneuropeptide Alleviates Motor and Cognitive Impairments in Neonatal Rats Following Hypoxic-Ischemic Brain Damage.

Yan Wang, Lei Xia, Bin Wu, Zhifang Dong, Yehong Du

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular neuroscience : MN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yan WangMinistry of Education Key Laboratory of Child Development and Disorders, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Lei XiaMinistry of Education Key Laboratory of Child Development and Disorders, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Bin WuMinistry of Education Key Laboratory of Child Development and Disorders, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Zhifang DongMinistry of Education Key Laboratory of Child Development and Disorders, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. zfdong@cqmu.edu.cn.ORCID http://orcid.org/0000-0002-3411-7923
Yehong DuMinistry of Education Key Laboratory of Child Development and Disorders, Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China. dudu0000807@126.com.
Children's Hospital of Chongqing Medical University · CN

Funding

Innovation Research Group at Institutions of Higher Education in Chongqing CXQTP19034Innovative Research Group Project of the National Natural Science Foundation of China cstc2020jcyj-zdxmX0004Innovative Research Group Project of the National Natural Science Foundation of China cstc2021ycjh-bgzxm0186National Natural Science Foundation of China 82001158National Natural Science Foundation of China 82071395National Natural Science Foundation of China 91749116National Natural Science Foundation of Chongqing cstc2019jcyj-bshX0016Science and Technology Research Program of Chongqing Municipal Education Commission KJZD-K201900403
6 · The paper itself

Abstract

Hypoxic-ischemic brain damage (HIBD) is among the leading causes of neonatal brain injury. ODN, a peptide derived from diazepam-binding inhibitor (DBI), has potent antioxidant and anti-apoptotic properties. It remains unclear, however, whether ODN is an effective treatment for HIBD. Here, we reported that treatment with ODN (10 ng/day, i.c.v.) alleviated the deficits in myodynamia and motor coordination and cognitive functions in HIBD. Meanwhile, ODN prevented the neuronal loss in the cortex and hippocampus in HIBD rats. In addition, ODN decreased ROS by generating less oxidants and more antioxidants, as reflected by a dramatic increase in total antioxidant capacity, glutathione reductase, and catalase and a marked decrease in H

Indexed as

Cognitive DysfunctionHypoxia-Ischemia, BrainAnimalsAnimals, NewbornAntioxidantsBrainDiazepam Binding InhibitorHydrogen PeroxideNeuropeptidesPeptide FragmentsRatsReactive Oxygen SpeciesAntioxidantsDiazepam Binding Inhibitordiazepam binding inhibitor (33-50)Hydrogen PeroxideNeuropeptidesPeptide FragmentsReactive Oxygen SpeciesCognitionHypoxic-ischemic brain damageODNOxidative stress

Identifiers

PMID35556218
OpenAlexW4280590358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.