Evidence map›Paper›PMID 35556152›Full record

ArticlePediatric radiology2022

Quantitative cardiopulmonary magnetic resonance imaging in neonatal congenital diaphragmatic hernia.

Jean A Tkach, Nara S Higano, Michael D Taylor, Ryan A Moore, Monir Hossain, Guixia Huang, David R Spielberg, Sean B Fain, Paul S Kingma, Jason C Woods

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jean A TkachDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229-3039, USA. jean.tkach@cchmc.org.ORCID 0000-0003-4593-7481
Nara S HiganoDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229-3039, USA.
Michael D TaylorDivision of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ryan A MooreDivision of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Monir HossainBiostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Guixia HuangBiostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
David R SpielbergDepartment of Pulmonary Medicine, Texas Children's Hospital, Houston, TX, USA.
Sean B FainDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Paul S KingmaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jason C WoodsDepartment of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229-3039, USA.
Cincinnati Children's Hospital Medical Center · USTexas Children's Hospital · USUniversity of Iowa · US

Funding

MRI Phenotyping of Severe BPD and Prediction of OutcomesR01HL146689 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI JASON C WOODS · 2019 to 2026
$4.6M
NHLBI NIH HHS R01 HL146689
6 · The paper itself

Abstract

backgroundPulmonary arterial hypertension, impaired cardiac function and lung hypoplasia are common in infants with congenital diaphragmatic hernia (CDH) and are associated with increased morbidity and mortality. Robust noninvasive methods to quantify these abnormalities in early infancy are lacking.

objectiveTo determine the feasibility of MRI to quantify cardiopulmonary hemodynamics and function in infants with CDH and to investigate left-right blood flow and lung volume discrepancies. MATERIALS AND

methodsWe conducted a prospective MRI study of 23 neonates (isolated left CDH: 4 pre-repair, 7 post-repair, 3 pre- and post-repair; and 9 controls) performed on a small-footprint 1.5-tesla (T) scanner. We calculated MRI-based pulmonary arterial blood flow, left ventricular eccentricity index, cardiac function and lung volume. Using the Wilcoxon rank sum test for continuous data and Fisher exact test for categorical data, we made pairwise group comparisons.

resultsThe right-to-left ratios for pulmonary artery blood flow and lung volume were elevated in pre-repair and post-repair CDH versus controls (flow: P<0.005; volume: P<0.05 pre-/post-repair). Eccentricity index at end-systole significantly differed between pre-repair and post-repair CDH (P<0.01) and between pre-repair CDH and controls (P<0.001).

conclusionCardiopulmonary MRI is a viable method to serially evaluate cardiopulmonary hemodynamics and function in critically ill infants and is useful for capturing left-right asymmetries in pulmonary blood flow and lung volume.

Indexed as

Hernias, Diaphragmatic, CongenitalHumansInfantInfant, NewbornLungLung Volume MeasurementsMagnetic Resonance ImagingProspective StudiesCardiac functionCongenital diaphragmatic herniaHeartInfantsLungsMagnetic resonance imagingNeonatal intensive care unitPulmonary blood flowPulmonary hypertension

Identifiers

PMID35556152
OpenAlexW4280584337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.