Evidence map›Paper›PMID 35554880›Full record

ArticlePharmacological reports : PR2022

Intrathecal pramipexole and selegiline for sensory and motor block in rats.

Chun-Chang Yeh, Chong-Chi Chiu, Jhi-Joung Wang, An-Kuo Chou, Yu-Wen Chen, Guan-Cheng Zhu, Ching-Hsia Hung

Abstract read
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In one paragraph

Article in Pharmacological reports : PR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chun-Chang Yeh *Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
Chong-Chi ChiuSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Jhi-Joung WangDepartment of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
An-Kuo Chou *Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.
Yu-Wen Chen *Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.
Guan-Cheng ZhuDepartment of Physical Therapy, College of Medicine, National Cheng Kung University, No.1 Ta-Hsueh Road, Tainan, Taiwan.
Ching-Hsia Hung *Department of Physical Therapy, College of Medicine, National Cheng Kung University, No.1 Ta-Hsueh Road, Tainan, Taiwan. chhung@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0001-6316-4342
China Medical University · TWNational Cheng Kung University · TWTri-Service General Hospital · TWE-Da Hospital · TW

Funding

China Medical University, Taiwan CMU110-MF-110Ministry of Science and Technology, Taiwan MOST 109-2918-I-039-001Ministry of Science and Technology, Taiwan MOST 110-2314-B-039-014-MY3
6 · The paper itself

Abstract

backgroundThe purpose of the study was to investigate spinal sensory and motor block by antiparkinsonian drugs (pramipexole and selegiline), and the combination of pramipexole and the local anesthetic lidocaine.

methodsUsing a technique of spinal blockade in rats, the effects of pramipexole, selegiline, and coadministration of pramipexole and lidocaine on spinal blockades of motor and sensory function were investigated.

resultsUnder a concentration of 100 mM, pramipexole displayed more potent and had a longer duration of nociceptive, proprioceptive, and motor block than selegiline, whereas pramipexole and selegiline were less potent in comparison to lidocaine. Pramipexole produced spinal nociceptive, proprioceptive, and motor blocks in a dose-related manner. On the ED

conclusionsPramipexole and selegiline were less potent than lidocaine to block sensory and motor responses. The duration of the spinal anesthetic effect of pramipexole was longer than lidocaine. At a non-effective dose, pramipexole increased the duration of efficacy of lidocaine.

Indexed as

Anesthesia, SpinalSelegilineAnesthetics, LocalAnimalsDose-Response Relationship, DrugInjections, SpinalLidocaineMotor ActivityNociceptionPramipexoleRatsRats, Sprague-DawleyAnesthetics, LocalLidocainePramipexoleSelegilineIntrathecal injectionMotor blockadePramipexoleSelegilineSensory blockade

Identifiers

PMID35554880
OpenAlexW4280564812

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.