ReviewInternational journal of biometeorology2022
Physiological mechanisms of the impact of heat during pregnancy and the clinical implications: review of the evidence from an expert group meeting.
Review in International journal of biometeorology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07489664 (Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat), which is not on this map. Cited by 110 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Indigenous Nutritional Supplements for Pregnancy to Improve Resilience in Environmental Heat
Who cites it
110 citing papers in PubMed, 6 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- A systematic review and meta-analysis on heat thresholds for maternal health and birth outcomes.Nature communications · 2026Pooled it
- A systematic review and meta-analysis of heat exposure impacts on maternal, fetal and neonatal health.Nature medicine · 2025Pooled it
- Evaluating the Impact of Heat Stress on Placental Function: A Systematic Review.International journal of environmental research and public health · 2024Pooled it
- Impacts of heat exposure in utero on long-term health and social outcomes: a systematic review.BMC pregnancy and childbirth · 2024Pooled it
- Acute association between heatwaves and stillbirth in six US states.Environmental health : a global access science source · 2022Pooled it
- Impact of ambient heat exposure on pregnancy outcomes in low- and middle-income countries: A systematic review.Women's health (London, England)Pooled it
- Aspirin and Preterm Birth Among Pregnant People With Increased Heat Exposure: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Heat stress and maternal complications in India: A nationwide analysis using the universal thermal climate index.iScience · 2026Article
- Association between extreme heat exposure and risk of preterm birth and its effect modifiers: a systematic review and meta-analysis.Journal of exposure science & environmental epidemiology · 2026Article
- Heat exposure and maternal stress: evidence from the GRAPHS pregnancy cohort in Ghana.Environmental research, health : ERH · 2026Article
- Expert consensus on passive heating interventions to promote skeletal muscle strength and mass: a delphi study.European journal of applied physiology · 2026Article
- Investigating environmental heat exposure and its effects on maternal and fetal health in rural Northern Ghana (Physio-HeMAB Study): a study protocol for a cluster randomized trial.BMC public health · 2026Article
- Comparing the health implications of heat exposure in pregnant women in rural and urban Tamil Nadu: An exploratory cohort study.BMC pregnancy and childbirth · 2026Observational
- Association between ambient temperature exposure and pregnancy outcomes in participants undergoing IVF: a retrospective cohort study.Journal of assisted reproduction and genetics · 2026Article
- Intersection of Climate and Environmental Change and Priority Health Outcomes Across the Life Course: Working Group 1 Report from the "Agriculture and Diet: Value Added for Nutrition, Translation, and Adaptation in a Global Ecology" (ADVANTAGE) Project.Advances in nutrition (Bethesda, Md.) · 2026Review
- Urban-rural disparities in heatwave effects on under-5 mortality in China, 2009-2019: a nationwide case-crossover study.The Lancet regional health. Western Pacific · 2026Article
- Increased Vulnerability to Dehydration Due to Heat Stress and Drought Across Reproductive States for Pastoralist Women in Northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- [Association between periconception maternal cold and heat exposure and the risk of congenital heart disease in offspring in China].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Safeguarding maternal health against extreme heat in India: A policy analysis of state-level heat action plans.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Temporal trends in late-pregnancy exposure to ambient temperature and risk of preterm birth in Japan, a nationwide study from 1979 to 2023.The Lancet regional health. Western Pacific · 2026Article
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 10 institutions in 8 countries.
Funding
Abstract
Many populations experience high seasonal temperatures. Pregnant women are considered vulnerable to extreme heat because ambient heat exposure has been linked to pregnancy complications including preterm birth and low birthweight. The physiological mechanisms that underpin these associations are poorly understood. We reviewed the existing research evidence to clarify the mechanisms that lead to adverse pregnancy outcomes in order to inform public health actions. A multi-disciplinary expert group met to review the existing evidence base and formulate a consensus regarding the physiological mechanisms that mediate the effect of high ambient temperature on pregnancy. A literature search was conducted in advance of the meeting to identify existing hypotheses and develop a series of questions and themes for discussion. Numerous hypotheses have been generated based on animal models and limited observational studies. There is growing evidence that pregnant women are able to appropriately thermoregulate; however, when exposed to extreme heat, there are a number of processes that may occur which could harm the mother or fetus including a reduction in placental blood flow, dehydration, and an inflammatory response that may trigger preterm birth. There is a lack of substantial evidence regarding the processes that cause heat exposure to harm pregnant women. Research is urgently needed to identify what causes the adverse outcomes in pregnancy related to high ambient temperatures so that the impact of climate change on pregnant women can be mitigated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.