ArticleSchizophrenia bulletin2022
Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical and neurobiological correlates of tardive dyskinesia in schizophrenia spectrum disorders and mood disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Transdiagnostic associations between subjective gesture behaviour and objective performance in schizophrenia and depression.Translational psychiatry · 2026Article
- Positive and negative falls short: why any attempt to rename schizophrenia must include careful consideration of the sensori-/psychomotor domain.European archives of psychiatry and clinical neuroscience · 2026Article
- The Association Between Childhood Impaired Motor Development and Adolescent Psychotic Experiences.Developmental psychobiology · 2025Article
- A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms.Schizophrenia bulletin · 2025Article
- Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments.Frontiers in psychiatry · 2025Article
- Article
- Motor precision deficits in clinical high risk for psychosis.European archives of psychiatry and clinical neuroscience · 2024Article
- Physical and mental health in adolescence: novel insights from a transdiagnostic examination of FitBit data in the ABCD study.Translational psychiatry · 2024Article
- The neural signature of psychomotor disturbance in depression.Molecular psychiatry · 2024Article
- Self-reported Gesture Interpretation and Performance Deficits in Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2023Article
- Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study.Biological psychiatry global open science · 2022Article
- (Developmental) Motor Signs: Reconceptualizing a Potential Transdiagnostic Marker of Psychopathological Vulnerability.Schizophrenia bulletin · 2022Article
- Motor Behavior is Relevant for Understanding Mechanism, Bolstering Prediction, And Improving Treatment: A Transdiagnostic Perspective.Schizophrenia bulletin · 2022Article
- Effect of Season of Birth on Hippocampus Volume in a Transdiagnostic Sample of Patients With Depression and Schizophrenia.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMotor abnormalities are strong transdiagnostic indicators of psychopathology risk that reflect emerging neural network abnormalities. Indeed, motor signs, such as motor slowing and agitation, are widely recognized as core features of both psychosis and depression. However, it is unclear whether these reflect shared or distinct etiology.
methodsA sample of 11 878 adolescents completed self-reported clinical measures of rated psychotic-like experiences (PLEs) and depression. Familial risk for psychopathology and the presence of motor signs were drawn from parental reports, including developmental motor delays (eg, sitting, walking), and adolescent motor signs (eg, dyscoordination, psychomotor retardation, and psychomotor agitation). Finally, motor network connectivity in theoretically relevant networks (cortico-striatal, cortico-thalamic, and cortico-cerebellar) were related to symptoms and familial risk for psychopathology.
resultsDevelopmental motor delays related to increased PLEs, increased depression symptoms, and greater familial risk. Familial risk for both PLEs and depression showed higher rates of developmental motor delays than all other groups. Adolescent motor signs, however, showed unique patterns of relationships to symptoms and familial risk such that dyscoordination reflected risk for PLEs, both psychomotor agitation and retardation reflected depression risk, and psychomotor agitation reflected transdiagnostic risk. Cortico-striatal connectivity was related to depression and PLEs, but cortico-cerebellar connectivity was linked to PLEs only.
conclusionsMotor signs may be a transdiagnostic marker of vulnerability for psychopathology. Early developmental motor delays could belie pluripotent, familial risk features. Unique items, eg, dyscoordination specifically related to PLEs, possibly reflecting processes inherent in distinct emerging forms of psychopathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.