Evidence map›Paper›PMID 35554593›Full record

ArticleSleep2022

Insomnia Diagnosis, Prescribed Hypnotic Medication Use, and Risk for Serious Fall Injuries in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

S Justin Thomas, Swati Sakhuja, Lisandro D Colantonio, Mei Li, Paul Muntner, Kristi Reynolds, C Barrett Bowling

Open access · bronzeAbstract read
In one paragraph

Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Function of Sleep and the Treatment of Primary Insomnia.Deutsches Arzteblatt international · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

S Justin ThomasUniversity of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-8709-4083
Swati SakhujaUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Lisandro D ColantonioUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Mei LiUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Paul MuntnerUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Kristi ReynoldsKaiser Permanente Southern California, Pasadena, CA, USA.
C Barrett BowlingDepartment of Veterans Affairs, Geriatric Research, Education, and Clinical Center, Durham, NC, USA.
University of Alabama at Birmingham · USDuke University · USKaiser Permanente · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Functional limitations during the transition to older ageR01AG062502 · NIA · DUKE UNIVERSITY · PI Christopher Barrett Bowling · 2020 to 2026
$3.4M
Ambulatory blood pressure and falls in older treated patients with hypertensionR01HL136445 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI REYNOLDS, KRISTI, SHIMBO, DAICHI · 2018 to 2021
$3.1M
NHLBI NIH HHS R01 HL136445NIA NIH HHSNIH HHS R01AG062502NINDS NIH HHSNINDS NIH HHS U01 NS041588VA
6 · The paper itself

Abstract

STUDY

objectivesInsomnia is common among older adults and associated with an increased risk for falls. Determining if falls are more strongly associated with insomnia or prescribed hypnotic medications could be used to guide interventions to reduce falls risk.

methodsWe examined the prospective association of a diagnosis of insomnia and/or prescribed hypnotic medication use with the risk for serious fall injuries among 9087 Reasons for Geographic and Racial Differences in Stroke (REGARDS) study participants aged 65 years or older with Medicare fee-for-service health insurance at baseline (2003-2007). A diagnosis of insomnia was based on ICD-9 codes in Medicare claims and prescribed hypnotic medication use was determined through a pill bottle review. Serious fall injuries were identified by Medicare claims between baseline and December 31, 2018.

resultsOver a median of 6.8 years, 1660 (18.3%) participants had a serious fall injury. The incidence rates for a serious fall injury per 1000 person-years were 24.8 (95%CI: 23.5, 26.1), 28.8 (95%CI: 18.6, 38.9), 32.6 (95%CI: 28.2, 37.0), and 46.6 (95%CI: 26.7, 66.5) for participants without insomnia or taking prescribed hypnotic medication (-insomnia/-hypnotics), with insomnia only (+insomnia/-hypnotics), taking prescribed hypnotic medication only (-insomnia/+hypnotics), and with insomnia and taking prescribed hypnotic medication (+insomnia/+hypnotics), respectively. Compared with the -insomnia/-hypnotic group, the multivariable-adjusted hazard ratios for a serious fall injury were 1.13 (95%CI: 0.79, 1.61), 1.29 (95%CI: 1.11, 1.50), and 1.60 (95%CI: 1.01, 2.56) for +insomnia/-hypnotics, -insomnia/+hypnotics, and +insomnia/+hypnotics, respectively.

conclusionsThe risk for serious fall injuries was higher for those taking prescribed hypnotic medications but not with an insomnia diagnosis.

Indexed as

Sleep Initiation and Maintenance DisordersStrokeAccidental FallsAgedHumansHypnotics and SedativesMedicareRace FactorsUnited StatesHypnotics and Sedativeshypnotic medicationinsomniaserious fall injuries

Identifiers

PMID35554593
PMCPMC9113010
OpenAlexW4221074739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.