ArticleSleep2022
Neurobehavioral morbidity of pediatric mild sleep-disordered breathing and obstructive sleep apnea.
Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome
Impact of Treatment of Mild Sleep-Disordered Breathing on Children's Health
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Advancements in pediatric obstructive sleep apnea: cognitive implications and the role of AI in precision medicine.Frontiers in medicine · 2025Pooled it
- Adenotonsillectomy vs Watchful Waiting in Pediatric Mild to Moderate Obstructive Sleep Apnea: The KATE Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2025Trial
- Symptoms, Quality of Life, and Executive Function in Children Who Snore.JAMA otolaryngology-- head & neck surgery · 2025Trial
- Adenotonsillectomy for Snoring and Mild Sleep Apnea in Children: A Randomized Clinical Trial.JAMA · 2023Trial
- Nighttime sleep duration and variability in children with obstructive sleep apnea syndrome: Sociodemographic disparities and neurobehavioral outcomes.Sleep medicine · 2023Trial
- Metabolomic Profiling in Children with Sleep Disorders: An Exploratory Pilot Study.Journal of clinical medicine · 2026Article
- Herpesvirus and Adenotonsillar Hypertrophy in Chinese Children: An Epidemiological and Clinical Analysis.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Regional Disruption of Slow-Wave Sleep Homeostasis in Children with Sleep-Disordered Breathing.medRxiv : the preprint server for health sciences · 2026Article
- Nocturnal hypoxemic burden in obesity hypoventilation syndrome compared to obstructive sleep apnea: a case-control study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Maxillary Arch Expansion and Adenotonsillectomy in Prepubertal Children Diagnosed with Paediatric Obstructive Sleep Apnoea: An Interventional Study.Journal of clinical medicine · 2026Article
- The Effect of Adenotonsillectomy on Sleep Efficiency in Pediatric Patients.Laryngoscope investigative otolaryngology · 2026Article
- Causal effects of modifiable risk factors on obstructive sleep apnea: A Mendelian randomization study and validation study.Medicine · 2026Article
- Journey Mapping the Unmet Needs in Pediatric Adenoid Hypertrophy: A Caregiver's Perspective.Nature and science of sleep · 2026Article
- Management of sleep-disordered breathing in achondroplasia: guiding principles of the European Achondroplasia Forum.Orphanet journal of rare diseases · 2025Article
- Analysis of Cognitive Levels and Influencing Factors in Children with Obstructive Sleep Apnea.Children (Basel, Switzerland) · 2024Article
- Ethnic/racial and sex disparities in obstructive sleep apnea among adolescents in southern California.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Altered Cortical Information Interaction During Respiratory Events in Children with Obstructive Sleep Apnea-Hypopnea Syndrome.Neuroscience bulletin · 2024Article
- Undergraduate dental sleep medicine teaching at German university dental schools - a questionnaire-based survey.BMC medical education · 2024Article
- Development and validation of a scale for the assessment of the knowledge-attitude-practice of parents towards children snoring.BMC primary care · 2024Review
- Neighborhood Disadvantage, Quality of Life, and Symptom Burden in Children with Mild Sleep-disordered Breathing.Annals of the American Thoracic Society · 2024Article
Corrections and comments
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Authors and funding
24 authors at 8 institutions in 1 country.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea is associated with neurobehavioral dysfunction, but the relationship between disease severity as measured by the apnea-hypopnea index and neurobehavioral morbidity is unclear. The objective of our study is to compare the neurobehavioral morbidity of mild sleep-disordered breathing versus obstructive sleep apnea.
methodsChildren 3-12 years old recruited for mild sleep-disordered breathing (snoring with obstructive apnea-hypopnea index < 3) into the Pediatric Adenotonsillectomy Trial for Snoring were compared to children 5-9 years old recruited for obstructive sleep apnea (obstructive apnea-hypopnea 2-30) into the Childhood Adenotonsillectomy Trial. Baseline demographic, polysomnographic, and neurobehavioral outcomes were compared using univariable and multivariable analysis.
resultsThe sample included 453 participants with obstructive sleep apnea (median obstructive apnea-hypopnea index 5.7) and 459 participants with mild sleep-disordered breathing (median obstructive apnea-hypopnea index 0.5). By polysomnography, participants with obstructive sleep apnea had poorer sleep efficiency and more arousals. Children with mild sleep-disordered breathing had more abnormal executive function scores (adjusted odds ratio 1.96, 95% CI 1.30-2.94) compared to children with obstructive sleep apnea. There were also elevated Conners scores for inattention (adjusted odds ratio 3.16, CI 1.98-5.02) and hyperactivity (adjusted odds ratio 2.82, CI 1.83-4.34) in children recruited for mild sleep-disordered breathing.
conclusionsAbnormal executive function, inattention, and hyperactivity were more common in symptomatic children recruited into a trial for mild sleep-disordered breathing compared to children recruited into a trial for obstructive sleep apnea. Young, snoring children with only minimally elevated apnea-hypopnea levels may still be at risk for deficits in executive function and attention.
trial registrationPediatric Adenotonsillectomy for Snoring (PATS), NCT02562040; Childhood Adenotonsillectomy Trial (CHAT), NCT00560859.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.