ArticleSleep2022
Neurotransmitters of sleep and wakefulness in flatworms.
Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
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- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Effects of Caffeine Exposure on Behaviour, Development and Physiology of the Freshwater SnailToxics · 2025Article
- Associations between gestational polybrominated diphenyl ether (PBDE) serum concentrations and child sleep outcomes from ages 2-8 years.Environmental research · 2025Article
- Can Theta Burst Electromagnetic Fields Disrupt Learning in Planaria? Evidence of Impaired Fear-Conditioned Responses.Bioelectromagnetics · 2025Article
- Sublethal Toxicity and Gene Expression Changes inNanomaterials (Basel, Switzerland) · 2025Article
- Total Alkaloid Extract of Nelumbinis Plumula Promoted Sleep in PCPA-Induced Insomnia Rats by Affecting Neurotransmitters and Their Receptor Activities.International journal of molecular sciences · 2025Article
- Article
- Lethal and Sublethal Toxicity of Nanosilver and Carbon Nanotube Composites toNanomaterials (Basel, Switzerland) · 2024Article
- Oxygen consumption rate of flatworms under the influence of wake- and sleep-promoting neurotransmitters.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- An electrophysiological correlate of sleep in a shark.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Maternal sleep deprivation disrupts glutamate metabolism in offspring rats.Zoological research · 2024Article
- Metabolic Characteristics of Gut Microbiota and Insomnia: Evidence from a Mendelian Randomization Analysis.Nutrients · 2024Article
- Why study sleep in flatworms?Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Review
- LPS and its relationship with subjective-objective discrepancies of sleep onset latency in patients with psychiatric disorders.Scientific reports · 2023Article
- Sleep-Enhancing Effect of Water Extract from Jujube (Foods (Basel, Switzerland) · 2023Article
- Persistence of Nocturnality in Decapitated and Bisected Flatworms.Journal of biological rhythms · 2023Article
- Does EGFR Signaling Mediate Orexin System Activity in Sleep Initiation?International journal of molecular sciences · 2023Review
- The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models.Clocks & sleep · 2023Review
- Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation.Frontiers in pharmacology · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSleep is a prominent behavioral and biochemical state observed in all animals studied, including platyhelminth flatworms. Investigations into the biochemical mechanisms associated with sleep-and wakefulness-are important for understanding how these states are regulated and how that regulation changed with the evolution of new types of animals. Unfortunately, beyond a handful of vertebrates, such studies on invertebrates are rare.
methodsWe investigated the effect of seven neurotransmitters, and one pharmacological compound, that modulate either sleep or wakefulness in mammals, on flatworms (Girardia tigrina). Flatworms were exposed via ingestion and diffusion to four neurotransmitters that promote wakefulness in vertebrates (acetylcholine, dopamine, glutamate, histamine), and three that induce sleep (adenosine, GABA, serotonin) along with the H1 histamine receptor antagonist pyrilamine. Compounds were administered over concentrations spanning three to five orders of magnitude. Flatworms were then transferred to fresh water and video recorded for analysis.
resultsDopamine and histamine decreased the time spent inactive and increased distance traveled, consistent with their wake-promoting effect in vertebrates and fruit flies; pyrilamine increased restfulness and GABA showed a nonsignificant trend towards promoting restfulness in a dose-dependent manner, in agreement with their sleep-inducing effect in vertebrates, fruit flies, and Hydra. Similar to Hydra, acetylcholine, glutamate, and serotonin, but also adenosine, had no apparent effect on flatworm behavior.
conclusionsThese data demonstrate the potential of neurotransmitters to regulate sleep and wakefulness in flatworms and highlight the conserved action of some neurotransmitters across species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.