Evidence map›Paper›PMID 35553398›Full record

Trial reportEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2022

Maternal vitamin D status in pregnancy and molar incisor hypomineralisation and hypomineralised second primary molars in the offspring at 7-9 years of age: a longitudinal study.

T Børsting, A Schuller, P van Dommelen, S N Stafne, M S Skeie, A B Skaare, S Mørkved, K Å Salvesen, A K Stunes, M P Mosti and 3 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 6 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 6 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Global prevalence of hypomineralised second primary molars: an updated systematic review with a meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Prevalence and characteristics of hypomineralised second primary molars in Irish school children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

T BørstingCenter for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway. torbo@tkmidt.no.ORCID http://orcid.org/0000-0002-8807-3807
A SchullerDepartment of Child Health, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-7759-2946
P van DommelenDepartment of Child Health, The Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
S N StafneDepartment of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0003-4922-477X
M S SkeieCenter for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.ORCID http://orcid.org/0000-0002-7888-4868
A B SkaareDepartment of Paediatric Dentistry and Behavioural Science, Faculty of Dentistry, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8106-2956
S MørkvedDepartment of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0002-7250-107X
K Å SalvesenDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0002-1788-4063
A K StunesDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0003-1074-5199
M P MostiDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0001-9819-5747
M K GustafssonDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0003-4151-393X
U SyversenDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID http://orcid.org/0000-0002-3607-7486
T N FagerhaugCenter for Oral Health Services and Research, Mid-Norway (TkMidt), Trondheim, Norway.ORCID http://orcid.org/0000-0001-6492-4075
Norwegian University of Science and Technology · NONetherlands Organisation for Applied Scientific Research · NLUniversity Medical Center Groningen · NLUniversity of Bergen · NOUniversity of Oslo · NO

Funding

Fysiofondet 7/370-00/05Samarbeidsorganet 2006/9264-95
6 · The paper itself

Abstract

purposeThe study aimed to investigate associations between maternal vitamin D status during pregnancy and molar incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) among children.

methodsThe study had a longitudinal design using prospectively collected data from 176 mother and child pairs. Mothers were initially recruited in a randomised controlled trial to assess a pregnancy exercise programme. Along with the 7-year follow-up, we invited the children to a dental examination. The exposure variable was maternal serum 25-hydroxyvitamin D in gestational weeks 18-22 and 32-36, categorised as insufficient (< 50 nmol/l) and sufficient (≥ 50 nmol/l). Negative binomial hurdle models were used to analyse potential associations between the exposure variables and MIH or HSPM. The models were adjusted for potential confounders.

resultsAmong the children (7-9 years old), 32% and 22% had at least one tooth with MIH or HSPM, respectively. A significant association was found between insufficient maternal vitamin D measured in gestational weeks 18-22 and the number of affected teeth among those with MIH at 7-9 years (adjusted RR = 1.82, 95% CI 1.13-2.93).

conclusionConsidering any limitations of the present study, it has been shown that insufficient maternal serum vitamin D at mid-pregnancy was associated with a higher number of affected teeth among the offspring with MIH at 7-9 years of age. Further prospective studies are needed to investigate whether this finding is replicable and to clarify the role of maternal vitamin D status during pregnancy and MIH, as well as HSPM, in children.

Indexed as

Dental Enamel HypoplasiaChildFemaleHumansLongitudinal StudiesMolarPregnancyPrevalenceVitamin DVitamin DDental cariesEnamel hypomineralisationHSPMMIHPregnancyVitamin D

Identifiers

PMID35553398
PMCPMC9338139
OpenAlexW4280592040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.