Evidence map›Paper›PMID 35552980›Full record

ArticleEndocrine2022

Association of antibiotics exposure within the first 2 years after birth with subsequent childhood type 1 diabetes.

Dahye Lee, Seulggie Choi, Jooyoung Chang, Young Jun Park, Jae Hyun Kim, Sang Min Park

Abstract read
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In one paragraph

Article in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Dahye LeeDepartment of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea.ORCID 0000-0002-4768-4468
Seulggie ChoiDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, South Korea.
Jooyoung ChangDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, South Korea.
Young Jun ParkDepartment of Family Medicine, Seoul National University Hospital, Seoul, South Korea.ORCID 0000-0001-6045-7406
Jae Hyun KimDepartment of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea.ORCID 0000-0002-0203-7443
Sang Min ParkDepartment of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, South Korea. smpark.snuh@gmail.com.
Seoul National University · KRSeoul National University Bundang Hospital · KRSeoul National University Children's Hospital · KRSeoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAntibiotics prescription in early life can cause dysbiosis, an imbalance of gut microbiota. We aimed to reveal the relationship between antibiotics exposure during the first 2 years after birth and type 1 diabetes risk in children under 8 years of age using a nationally representative data from South Korea.

methodsThe final study population consisted of 63,434 children from the National Health Insurance Service (NHIS) database from 2008 to 2015. The primary exposure of interest was antibiotics prescription in first 2 years after birth. The analysis was conducted with cumulative defined daily dose (cDDD; 0-29, 30-59, ≥ 60 cDDD), the number of antibiotics classes (0-3, 4, ≥5 classes), and age at first antibiotics prescription (0-119, 120-239, ≥ 240 days). Age, sex, household income, and overweight were considered as potential confounding covariates.

resultsCompared to those within the less than 30 cDDD, other groups that were prescribed more antibiotics did not have a significant difference in diabetes risk (aHR 0.86, 95% CI 0.37-2.02 in ≥ 60 cDDD). The number of antibiotics classes and age at first antibiotics prescriptions were also not associated with the risk of type 1 diabetes. The development of diabetes was not related to the cDDD, the number of antibiotics classes, and age at first antibiotics prescription according to subgroup analysis which was stratified by overweight.

conclusionsAntibiotics exposure within the first 2 years of life was not associated with subsequent diabetes risk. Future studies using a larger number of long-term follow-up data are needed.

Indexed as

Diabetes Mellitus, Type 1Gastrointestinal MicrobiomeAnti-Bacterial AgentsChildFemaleHumansOverweightParturitionPregnancyAnti-Bacterial AgentsAnti-bacterial agentsChildDiabetes mellitus, Type 1Dysbiosis

Identifiers

PMID35552980
OpenAlexW4280531892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.