ArticleCerebral cortex (New York, N.Y. : 1991)2023
A convergent structure-function substrate of cognitive imbalances in autism.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026Article
- Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.Molecular psychiatry · 2025Review
- Effects of Computerized Cognitive Training in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review.Journal of autism and developmental disorders · 2025Article
- Language networks in Autism Spectrum Disorder: A systematic review of connectivity-based fMRI studies.Review journal of autism and developmental disorders · 2025Article
- Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder.Molecular autism · 2024Article
- Contracted functional connectivity profiles in autism.Molecular autism · 2024Article
- Diverging asymmetry of intrinsic functional organization in autism.Molecular psychiatry · 2023Article
- Altered Relationship between Functional Connectivity and Fiber-Bundle Structure in High-Functioning Male Adults with Autism Spectrum Disorder.Brain sciences · 2023Article
- Different levels of visuospatial abilities linked to differential brain correlates underlying visual mental segmentation processes in autism.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Autism-ness Does Not Exist, but Autism Does. Part 1: A Critic of the "Spectrum" Position Used to Describe, Diagnose, and Research Autism, and Its Alternative.Autism & developmental language impairmentsArticle
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundAutism spectrum disorder (ASD) is a common neurodevelopmental diagnosis showing substantial phenotypic heterogeneity. A leading example can be found in verbal and nonverbal cognitive skills, which vary from elevated to impaired compared with neurotypical individuals. Moreover, deficits in verbal profiles often coexist with normal or superior performance in the nonverbal domain.
methodsTo study brain substrates underlying cognitive imbalance in ASD, we capitalized categorical and dimensional IQ profiling as well as multimodal neuroimaging.
resultsIQ analyses revealed a marked verbal to nonverbal IQ imbalance in ASD across 2 datasets (Dataset-1: 155 ASD, 151 controls; Dataset-2: 270 ASD, 490 controls). Neuroimaging analysis in Dataset-1 revealed a structure-function substrate of cognitive imbalance, characterized by atypical cortical thickening and altered functional integration of language networks alongside sensory and higher cognitive areas.
conclusionAlthough verbal and nonverbal intelligence have been considered as specifiers unrelated to autism diagnosis, our results indicate that intelligence disparities are accentuated in ASD and reflected by a consistent structure-function substrate affecting multiple brain networks. Our findings motivate the incorporation of cognitive imbalances in future autism research, which may help to parse the phenotypic heterogeneity and inform intervention-oriented subtyping in ASD.
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