Evidence map›Paper›PMID 35552463›Full record

Trial reportScientific reports2022

Functional in-vitro evaluation of the non-specific effects of BCG vaccination in a randomised controlled clinical study.

Morven Wilkie, Rachel Tanner, Daniel Wright, Raquel Lopez Ramon, Julia Beglov, Michael Riste, Julia L Marshall, Stephanie A Harris, Paulo J G Bettencourt, Ali Hamidi and 5 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02380508 (Evaluation of the Heterologous Effects of Bacille Calmette-Guérin), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02380508 nacompletednot on this map

Evaluation of the Heterologous Effects of Bacille Calmette-Guérin (BCG) Vaccination in Healthy UK Adults

TypeinterventionalSponsorUniversity of OxfordRan2015 to 2016Enrolled36ConditionsTuberculosisArmsBCG SSI, No vaccination, BCG Sii
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Morven Wilkie *Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Rachel Tanner *Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK. rachel.tanner@ndm.ox.ac.uk.
Daniel WrightJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Raquel Lopez RamonJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Julia BeglovJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Michael RisteJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Julia L MarshallJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Stephanie A HarrisJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Paulo J G BettencourtJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Ali HamidiJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Pauline M van DiemenJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Paul MossDepartment of Infection and Tropical Medicine, Birmingham Heartlands Hospital, Birmingham, B9 5SS, UK.
Iman SattiJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
David WyllieJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
Helen McShaneJenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK. helen.mcshane@ndm.ox.ac.uk.
Jenner Institute · GBUniversity of Oxford · GBHeartlands Hospital · GBChelsea and Westminster Hospital · GB

Funding

Bill & Melinda Gates Foundation OPP1112389Department of HealthWellcome TrustWellcome Trust WT 206331/Z/17/Z
6 · The paper itself

Abstract

Bacille Calmette-Guérin (BCG), the only currently licenced tuberculosis vaccine, may exert beneficial non-specific effects (NSE) in reducing infant mortality. We conducted a randomised controlled clinical study in healthy UK adults to evaluate potential NSE using functional in-vitro growth inhibition assays (GIAs) as a surrogate of protection from four bacteria implicated in infant mortality. Volunteers were randomised to receive BCG intradermally (n = 27) or to be unvaccinated (n = 8) and were followed up for 84 days; laboratory staff were blinded until completion of the final visit. Using GIAs based on peripheral blood mononuclear cells, we observed a significant reduction in the growth of the Gram-negative bacteria Escherichia coli and Klebsiella pneumonia following BCG vaccination, but no effect for the Gram-positive bacteria Staphylococcus aureus and Streptococcus agalactiae. There was a modest association between S. aureus nasal carriage and growth of S. aureus in the GIA. Our findings support a causal link between BCG vaccination and improved ability to control growth of heterologous bacteria. Unbiased assays such as GIAs are potentially useful tools for the assessment of non-specific as well as specific effects of TB vaccines. This study was funded by the Bill and Melinda Gates Foundation and registered with ClinicalTrials.gov (NCT02380508, 05/03/2015; completed).

Indexed as

BCG VaccineTuberculosis VaccinesAdultHumansInfantLeukocytes, MononuclearStaphylococcus aureusVaccinationBCG VaccineTuberculosis Vaccines

Identifiers

PMID35552463
PMCPMC9096342
OpenAlexW4280517589

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.