ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Vigilance and Behavioral State-Dependent Modulation of Cortical Neuronal Activity throughout the Sleep/Wake Cycle.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Article
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- Rhythmic and arrhythmic components from local-field potentials during non-rapid eye movement sleep in younger and older mice.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025Article
- Acute REM sleep deprivation alleviated depression-like behavior mediated by inhibiting VIP neurons in the mPFC.Science advances · 2025Article
- Layer 1 NDNF interneurons form distinct subpopulations with opposite activation patterns during sleep in freely behaving mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- A Role for δ Subunit-Containing GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neocortical somatostatin neuron diversity in cognition and learning.Trends in neurosciences · 2025Review
- Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.Nature communications · 2024Article
- Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Article
- Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.The EMBO journal · 2023Article
- Cortical Inhibition, Plasticity, and Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GABAergic inhibitory neurons, through their molecular, anatomic, and physiological diversity, provide a substrate for the modulation of ongoing cortical circuit activity throughout the sleep/wake cycle. Here, we investigated neuronal activity dynamics of parvalbumin (PV), vasoactive intestinal polypeptide (VIP), and somatostatin (SST) neurons in naturally sleeping head-restrained mice at the level of layer 2/3 of the primary somatosensory barrel cortex of mice. Through calcium imaging and targeted single-unit loose-patch or whole-cell recordings, we found that PV action potential firing activity was largest during both rapid eye movement (REM) and nonrapid eye movement (NREM) sleep stages, that VIP neurons were most active during REM sleep, and that the overall activity of SST neurons remained stable throughout the sleep/wake cycle. Analysis of neuronal activity dynamics uncovered rapid decreases in PV cell firing at wake onset followed by a progressive recovery during wake. Simultaneous local field potential (LFP) recordings further revealed that except for SST neurons, a large proportion of neurons were modulated by ongoing delta and theta oscillations. During NREM sleep spindles, PV and SST activity increased and decreased, respectively. Finally, we uncovered the presence of whisking behavior in mice during REM sleep and show that the activity of VIP and SST is differentially modulated during awake and sleeping whisking bouts, which may provide a neuronal substrate for internal brain representations occurring during sleep.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.