Evidence map›Paper›PMID 35551989›Full record

ArticleNeuroImage2022

Phenotypic and genetic associations between gray matter covariation and tool use skill in chimpanzees (Pan troglodytes): Repeatability in two genetically isolated populations.

M M Mulholland, S J Schapiro, C C Sherwood, W D Hopkins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M M MulhollandDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, 650 Cool Water Drive, Bastrop, TX 78602, USA. Electronic address: mmmulholland@mdanderson.org.
S J SchapiroDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, 650 Cool Water Drive, Bastrop, TX 78602, USA; Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark.
C C SherwoodDepartment of Anthropology and Center for the Advanced Study of Human Paleobiology, The George Washington University, Washington, DC 20052, USA.
W D HopkinsDepartment of Comparative Medicine, The University of Texas MD Anderson Cancer Center, 650 Cool Water Drive, Bastrop, TX 78602, USA.

Funding

The National Center for Chimpanzee CareU42OD011197 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAGDEN, ELIZABETH · 2012 to 2019
$19.7M
Alzheimer's Disease Pathology in a Primate ModelR01AG067419 · NIA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HOPKINS, WILLIAM D · 2021 to 2025
$3.8M
Hemispheric Specialization and CommunicationR01NS042867 · NINDS · GEORGIA STATE UNIVERSITY · PI HOPKINS, WILLIAM D · 2002 to 2015
$3.3M
Heritability of Neuroanatomical Asymmetries in PrimatesR01NS073134 · NINDS · GEORGIA STATE UNIVERSITY · PI HOPKINS, WILLIAM D · 2011 to 2014
$1.2M
A National Chimpanzee Brain ResourceR24NS092988 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI SHERWOOD, CHESTER · 2015 to 2018
$969k
NIA NIH HHS R01 AG067419NIH HHS U42 OD011197NINDS NIH HHS R01 NS042867NINDS NIH HHS R01 NS073134NINDS NIH HHS R24 NS092988
6 · The paper itself

Abstract

Humans and chimpanzees both exhibit a diverse set of tool use skills which suggests selection for tool manufacture and use occurred in the common ancestors of the two species. Our group has previously reported phenotypic and genetic associations between tool use skill and gray matter covariation, as quantified by source-based morphometry (SBM), in chimpanzees. As a follow up study, here we evaluated repeatability in heritability in SBM components and their phenotypic association with tool use skill in two genetically independent chimpanzee cohorts. Within the two independent cohorts of chimpanzees, we identified 8 and 16 SBM components, respectively. Significant heritability was evident for multiple SBM components within both cohorts. Further, phenotypic associations between tool use performance and the SBM components were largely consistent between the two cohorts; the most consistent finding being an association between tool use performance and an SBM component including the posterior superior temporal sulcus (STS) and superior temporal gyrus (STG), and the interior and superior parietal regions (p < 0.05). These findings indicate that the STS, STG, and parietal cortices are phenotypically and genetically implicated in chimpanzee tool use abilities.

Indexed as

Pan troglodytesTool Use BehaviorAnimalsFollow-Up StudiesGray MatterHumansTemporal LobeChimpanzeeHeritabilitySource-based morphometryTool use

Identifiers

PMID35551989
PMCPMC9351395

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.