ArticleThe American journal of clinical nutrition2022
Adherence to the Mediterranean-style diet and high intake of total carotenoids reduces the odds of frailty over 11 years in older adults: Results from the Framingham Offspring Study.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Network Analysis of Food Intake Patterns and Frailty Dimensions in Chinese Older Adults: A National Cross-Sectional Study.Nutrients · 2026Article
- The application value of frailty assessment tools in the perioperative period: A narrative review.Journal of anesthesia and translational medicine · 2026Review
- Longevity, Centenarians, and Lifestyle: Any ''Tips'' to Live Longer?Current nutrition reports · 2026Review
- Intake of dietary carotenoids and flavonoids at midlife and risk of physical frailty at late life: the Singapore Chinese Health Study.Nutrition journal · 2025Article
- Article
- Association Between Ultra-Processed Food Consumption Frequency and Frailty: Findings from the InCHIANTI Study of Aging.Geriatrics (Basel, Switzerland) · 2025Article
- Ultra-Processed Food and Frailty: Evidence from a Prospective Cohort Study and Implications for Future Research.Nutrients · 2025Article
- Berries and Steps: a protocol of a randomized, placebo-controlled pilot study testing freeze-dried blueberry powder in sedentary older adults with mild depressive symptoms.Nutrition journal · 2025Article
- Influence of Dietary Habits on Macular Pigment in Childhood.Journal of clinical medicine · 2025Article
- The Relationship Between a Mediterranean Diet and Frailty in Older Adults: NHANES 2007-2017.Nutrients · 2025Article
- Predicting the unseen: nutritional interventions as a key to combat frailty.Frontiers in nutrition · 2025Article
- Dietary inflammatory index, dietary total antioxidant capacity, and frailty among older Chinese adults.The journal of nutrition, health & aging · 2024Article
- The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress.Clinical interventions in aging · 2024Article
- Dietary Patterns and Healthy or Unhealthy Aging.Gerontology · 2024Review
- Mediterranean diet associated with lower frailty risk: A large cohort study of 21,643 women admitted to hospitals.The journal of nutrition, health & aging · 2024Article
- Associations between Low-Carbohydrate Diets and Low-Fat Diets with Frailty in Community-Dwelling Aging Chinese Adults.Nutrients · 2023Article
- Higher intake of dietary flavonols, specifically dietary quercetin, is associated with lower odds of frailty onset over 12 years of follow-up among adults in the Framingham Heart Study.The American journal of clinical nutrition · 2023Article
- Dairy Food Intake Is Not Associated With Frailty in Adults From the Framingham Heart Study.Journal of the Academy of Nutrition and Dietetics · 2023Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe benefit of a Mediterranean-style diet in reducing frailty is not well established in older Americans.
objectivesWe sought to determine associations of a Mediterranean-style dietary pattern and related antioxidants with frailty onset and worsening of the Fried phenotype in adults.
methodsThis prospective study included 2384 nonfrail adults from the Framingham Offspring Study with a Mediterranean-style dietary pattern score (MSDPS) and data on antioxidant intakes (vitamin C, E, and total carotenoids) estimated from an FFQ at the index examination (1998-2001) and 1 prior examination (if available), as well as a frailty assessment at the index examination and at least 1 follow-up. Frailty onset was defined as ≥3 of 5 Fried frailty phenotype criteria at follow-up and the worsening of the Fried frailty phenotype was defined as an increased number of frailty criteria over follow-up (yes or no). Logistic regression with generalized estimating equations estimated ORs and 95% CIs, adjusting for confounders. Analyses were stratified by age (<60 and ≥60 years) for significant interactions.
resultsThe mean ± SD age was 60 ± 9 years (range, 33-86 years) and 55% were female. In adjusted models, a 1-unit higher MSDPS reduced the odds of frailty by 3% (OR, 0.97; 95% CI: 0.96-0.99). Each 10-mg higher total carotenoid and vitamin E intake reduced the odds of frailty by 16% (OR, 0.84; 95% CI: 0.73-0.98) and 1% (OR, 0.99; 95% CI: 0.98-1.00), respectively. No association with vitamin C (P = 0.36) was observed. The associations among participants aged <60 years of age were stronger for each 1-unit higher MSDPS (OR, 0.93; 95% CI: 0.89-0.96) and total carotenoid intake (OR, 0.59; 95% CI: 0.41-0.82) than those observed in older individuals [ORs, 0.98 (95% CI: 0.97-1.00) and 0.92 (95% CI: 0.79-1.08), respectively].
conclusionsOur findings suggest that adherence to a Mediterranean-style diet and higher total carotenoid intake are associated with frailty prevention over time, particularly in adults <60 years.
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