ArticleAMB Express2022
A myxobacterial GH19 lysozyme with bacteriolytic activity on both Gram-positive and negative phytopathogens.
Article in AMB Express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- An ancient lysozyme in placozoans participates in acidic extracellular digestion.Communications biology · 2026Article
- Myxobacteria: Versatile cell factories of novel commercial enzymes for bio-manufacturing.Biotechnology advances · 2025Review
- Genomic insights into novel predatory myxobacteria isolated from human feces.Microbiology spectrum · 2025Article
- Comparative genomic insight into the myxobacterial carbohydrate-degrading potential.Frontiers in microbiology · 2025Article
- The type II secretion system as an underappreciated and understudied mediator of interbacterial antagonism.Infection and immunity · 2024Review
- Secretory CAZymes profile and GH19 enzymes analysis ofFrontiers in microbiology · 2024Article
- Lysis profile and preference ofFrontiers in microbiology · 2023Article
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Authors and funding
9 authors.
Funding
Abstract
Myxobacteria, as predatory bacteria, have good application potential in the biocontrol of pathogenic microorganisms. Extracellular enzymes are thought to play an important role in their predation and also provide resources for discovering new antibacterial molecules. We previously isolated a myxobacterium, Corallococcus silvisoli c25j21 GDMCC 1.1387, which is predatory to plant pathogenic bacteria. In this study, we identified an endolysin-like GH19 glycoside hydrolase, C25GH19B, from the genome of c25j21. After its heterologous expression and purification from E. coli, the enzymatic properties of C25GH19B were characterized. C25GH19B showed lysozyme activity with the optimal reaction conditions at 40 °C and pH 4.5-5.0. Moreover, C25GH19B showed bacteriolytic activity against both Gram-positive and Gram-negative plant pathogenic bacteria. Our research provides not only a candidate enzyme for the development of novel biocontrol agents but also an experimental basis for further study on the function and mechanisms of extracellular enzymes in myxobacterial predation.
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