Evidence map›Paper›PMID 35551502›Full record

ArticleEuropean journal of human genetics : EJHG2023

Changes in opinions about human germline gene editing as a result of the Dutch DNA-dialogue project.

Diewertje Houtman, Boy Vijlbrief, Marike Polak, Jacqueline Pot, Petra Verhoef, Martina Cornel, Sam Riedijk

Erratum issuedAbstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Ethics of Human Embryo Editing via CRISPR-Cas9 Technology: A Systematic Review of Ethical Arguments, Reasons, and Concerns.HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Diewertje HoutmanDepartment of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-0661-6466
Boy VijlbriefDepartment of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Marike PolakDepartment of Psychology, Education and Child Studies (DPECS), Erasmus University Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-5012-5480
Jacqueline PotErfocentrum, Amersfoort, The Netherlands.
Petra VerhoefRathenau Instituut, The Hague, The Netherlands.
Martina CornelDepartment of Human Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-5397-5544
Sam RiedijkDepartment of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. s.riedijk@erasmusmc.nl.ORCID 0000-0003-3400-4969

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Public engagement for Human Germline Genome Editing (HGGE) has often been called for, for example by the WHO. However, the impact of public engagement remains largely unknown. This study reports on public engagement outcomes in the context of a public dialogue project about HGGE in the Netherlands; the DNA-dialogue. The aim was to inquire opinions and opinion change regarding HGGE. A questionnaire was distributed on a national level (n = 2381) and a dialogue level (n = 414). The results indicate that the majority of the Dutch population agrees with the use of HGGE to prevent severe genetic diseases (68.6%), unlike the use to protect against infectious diseases (39.7%), or for enhancement (8.5%). No indications of change in these acceptance rates as a result of dialogue participation were found. The results did provide a tentative indication that participation in dialogue may lead to less negative opinions about HGGE (χ

Indexed as

AttitudeGene EditingDNAGenome, HumanGerm CellsHumansDNA

Identifiers

PMID35551502
PMCPMC9095815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.