Evidence map›Paper›PMID 35551464›Full record

ReviewJournal of cancer research and clinical oncology2022

Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer.

Nicole M Myer, Kohei Shitara, Hyun C Chung, Florian Lordick, Ronan J Kelly, Zsolt Szabo, Z Alexander Cao, Stephen Leong, David H Ilson, Wilko Weichert

Abstract readReview
In one paragraph

Review in Journal of cancer research and clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. APOL2 Stabilizes Ku80 to Confer NHEJ-Mediated Radioresistance in Gastric Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Immunotherapy for metastatic gastric cancer.World journal of gastrointestinal surgery · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicole M MyerMerck & Co., Inc., 90 E. Scott Avenue, Rahway, NJ, 07065, USA. nicole.myer@merck.com.ORCID http://orcid.org/0000-0002-9053-1037
Kohei ShitaraDepartment of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
Hyun C ChungDivision of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
Florian LordickMedical Department (Oncology, Gastroenterology, Hepatology, Pulmonology, and Infectious Diseases), University Cancer Center Leipzig (UCCL), Leipzig University Medical Center, Leipzig, Germany.
Ronan J KellyCharles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA.
Zsolt SzaboMerck & Co., Inc., Ringstrasse 27 Kriens, LUZERN, 6010, Switzerland.
Z Alexander CaoMerck & Co., Inc., 90 E. Scott Avenue, Rahway, NJ, 07065, USA.
Stephen LeongMerck & Co., Inc., 351 N Sumneytown Pike, North Wales, PA, 19454, USA.
David H IlsonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wilko WeichertInstitute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

Indexed as

Stomach NeoplasmsB7-H1 AntigenBiomarkers, TumorHumansMicrosatellite InstabilityPrognosisB7-H1 AntigenBiomarkers, TumorBiomarkersGastric cancerMicrosatellite instabilityProgrammed death ligand 1Tumor mutational burden

Identifiers

PMID35551464
PMCPMC11110882

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.