Evidence map›Paper›PMID 35551444›Full record

ArticleNature communications2022

Multimodal CEA-targeted fluorescence and radioguided cytoreductive surgery for peritoneal metastases of colorectal origin.

Jan Marie de Gooyer, Fortuné M K Elekonawo, Andreas J A Bremers, Otto C Boerman, Erik H J G Aarntzen, Philip R de Reuver, Iris D Nagtegaal, Mark Rijpkema, Johannes H W de Wilt

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase I
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03699332 (A Phase I/II Study to Evaluate the Safety and Feasibility of Multi-modality Imaging Using Indium-111-DOTA-labetuzumab-IRDye800CW in Patients With Peritoneal Carcinomatosis of Colorectal Origin), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03699332 phase1 / phase2unknown statusnot on this map

A Phase I/II Study to Evaluate the Safety and Feasibility of Multi-modality Imaging Using Indium-111-DOTA-labetuzumab-IRDye800CW in Patients With Peritoneal Carcinomatosis of Colorectal Origin

TypeinterventionalSponsorRadboud University Medical CenterRan2018 to 2021Enrolled29ConditionsPeritoneal Carcinomatosis, Colorectal Cancer, Carcinoma, NeoplasmsArmsIndium-111-DOTA-Labetuzumab-IRDye800CW injection, SPECT/CT scan, CRS extended with dual-modality imaging
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  4. Translation of Intraoperative Molecular Imaging for Clinical Use.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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  10. Advancements in Intraoperative Imaging for Enhanced Surgical Precision.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jan Marie de Gooyer *Department of Medical Imaging, Nuclear medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. jan-marie.gooyer@radboudumc.nl.ORCID 0000-0002-4636-5617
Fortuné M K Elekonawo *Department of Medical Imaging, Nuclear medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-1726-186X
Andreas J A BremersDepartment of Surgery Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Otto C BoermanDepartment of Medical Imaging, Nuclear medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Erik H J G AarntzenDepartment of Medical Imaging, Nuclear medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Philip R de ReuverDepartment of Surgery Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Iris D NagtegaalDepartment of pathology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-0887-4127
Mark RijpkemaDepartment of Medical Imaging, Nuclear medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Johannes H W de WiltDepartment of Surgery Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0001-6773-9668
Radboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In patients with colorectal peritoneal metastases scheduled for cytoreductive surgery, accurate preoperative estimation of tumor burden and subsequent intraoperative detection of all tumor deposits remains challenging. In this study (ClinicalTrials.gov NCT03699332) we describe the results of a phase I clinical trial evaluating [

Indexed as

Colorectal NeoplasmsPeritoneal NeoplasmsAntibodies, MonoclonalCarcinoembryonic AntigenCytoreduction Surgical ProceduresHumansOptical ImagingAntibodies, MonoclonalCarcinoembryonic Antigen

Identifiers

PMID35551444
PMCPMC9098887
OpenAlexW4280506603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.