Evidence map›Paper›PMID 35551077›Full record

Observational studyBMJ open2022

Association between symptoms and risk of non-ST segment elevation myocardial infarction according to age and sex in patients admitted to the emergency department with suspected acute coronary syndrome: a single-centre retrospective cohort study.

Ole-Thomas Steiro, Kristin Moberg Aakre, Hilde Lunde Tjora, Rune Oskar Bjørneklett, Øyvind Skadberg, Vernon Vijay Singha Bonarjee, Øistein Rønneberg Mjelva, Torbjorn Omland, Kjell Vikenes, Jørund Langørgen

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02620202 (Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02620202 terminatednot on this map

Aiming Towards Evidence Based Interpretation of Cardiac Biomarkers in Patients Presenting With Chest Pain (WESTCOR Study)

TypeobservationalSponsorHaukeland University HospitalRan2015 to 2020Enrolled1,900ConditionsAcute Coronary Syndrome
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ole-Thomas SteiroDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway ole-thomas.steiro@helse-bergen.no.ORCID 0000-0003-2520-9436
Kristin Moberg AakreDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0002-7340-6736
Hilde Lunde TjoraEmergency Care Clinic, Haukeland University Hospital, Bergen, Norway.
Rune Oskar BjørneklettEmergency Care Clinic, Haukeland University Hospital, Bergen, Norway.
Øyvind SkadbergLaboratory of Medical Biochemistry, Stavanger University Hospital, Stavanger, Norway.
Vernon Vijay Singha BonarjeeDepartment of Cardiology, Helse Stavanger HF, Stavanger, Norway.
Øistein Rønneberg MjelvaDepartment of Clinical Science, Haukeland University Hospital, Bergen, Norway.
Torbjorn OmlandInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Kjell VikenesDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Jørund LangørgenDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEvaluate the association between symptoms and risk of non-ST segment elevation myocardial infarction (NSTEMI) in patients admitted to an emergency department with suspected acute coronary syndrome based on sex and age.

designPost hoc analysis of a prospective observational study conducted between September 2015 and May 2019.

settingUniversity hospital in Norway.

participants1506 participants >18 years of age (39.6% women and 31.0% 70 years of age or older).

findingsThe OR for NSTEMI was 9.4 if pain radiated to both arms, 3.0 if exertional chest pain was present during the last week and 2.9 if pain occurred during activity. Men had significantly lower OR compared with women if pain was dependent of position, respiration or palpation (OR 0.17 vs 0.53, p value for interaction 0.047). Patients <70 years had higher predictive value than older patients if they reported exertional chest pain the last week (OR 4.08 vs 1.81, 95%, p value for interaction 0.025) and lower if pain radiated to the left arm (OR 0.73 vs 1.67, p value for interaction 0.045).

conclusionsChest pain with radiation to both arms, exertional chest pain during the last week and pain during activity had the strongest predictive value for NSTEMI. The differences in symptom presentation and risk of NSTEMI between sex and age groups were small. TRIAL REGISTRATION NUMBER: WESTCOR study ClinicalTrials.gov (NCT02620202).

Indexed as

Acute Coronary SyndromeNon-ST Elevated Myocardial InfarctionST Elevation Myocardial InfarctionAgedChest PainEmergency Service, HospitalFemaleHumansMaleRetrospective StudiesRisk Factorscoronary heart diseaseischaemic heart diseasemyocardial infarction

Identifiers

PMID35551077
PMCPMC9109031

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.