SynthesisPsychological medicine2022
Actigraphically measured psychomotor slowing in depression: systematic review and meta-analysis.
Synthesis in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes.BMC psychiatry · 2026Trial
- Impact of Activation Therapy for Inpatients With Major Depression: Primary and Secondary Outcomes From a Randomised Controlled Trial.Bipolar disorders · 2025Trial
- Long-term outcomes of physical activity counseling in in-patients with major depressive disorder: results from the PACINPAT randomized controlled trial.Translational psychiatry · 2024Trial
- Measuring psychomotor agitation via hand tremor in remitted major depressive disorder.Journal of psychiatric research · 2026Article
- Study protocol of a randomized controlled trial for the effectiveness of psychomotor therapy on quality of life and psychomotor skills in depression.BMC psychiatry · 2026Article
- The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit.Acta pharmacologica Sinica · 2026Article
- Motor Abnormalities and the Hierarchical Taxonomy of Psychopathology: Incorporating a Psychomotor Perspective Into a Hierarchical Dimensional Symptom Framework.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Sleep and Activity Patterns in Depression From Wearable Data: Unsupervised Clustering Study.Journal of medical Internet research · 2026Article
- Depression symptoms relate to altered brain connectivity and behavioral responses during self-referential judgments.Cognitive, affective & behavioral neuroscience · 2026Article
- Characterizing Physical Activity Trajectories Preceding Incident Major Depressive Disorder Diagnosis With Consumer Wearable Devices in the All of Us Research Program: Retrospective Nested Case-Control Study.Journal of medical Internet research · 2026Article
- Transdiagnostic Patterns of Grip Strength in Schizophrenia, Current Depression, and Remitted Depression.JAMA psychiatry · 2026Article
- Daily steps offset risks of sedentary behavior in the All of Us research program.Nature communications · 2026Article
- Multimodal Virtual Reality Assessment of Medication Effects in Attention-Deficit/Hyperactivity Disorder and Its Distinction From Depression: Cross-Sectional Study.JMIR human factors · 2026Article
- Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.Brain : a journal of neurology · 2026Review
- Network analysis of social isolation, loneliness, depression and anxiety among post-discharge rehabilitation patients.Frontiers in psychiatry · 2026Article
- A Sleep and Circadian Biomarker-Based Predictive Model for Differentiating Unipolar and Bipolar Depression.Depression and anxiety · 2026Article
- Experiences and impact of chronic pain in South Africans living in a rural area: a qualitative study.BMJ open · 2025Article
- Visuomotor dysconnectivity as a candidate mechanism of psychomotor agitation in major depression.Psychological medicine · 2025Article
- Automatic quantification of hand gestures in current and remitted Major Depressive Disorder during oral expression.Journal of affective disorders · 2025Article
- Motor circuits and beyond: Functional connectivity related to psychomotor syndromes in depression.Psychological medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Psychomotor slowing is a key feature of depressive disorders. Despite its great clinical importance, the pathophysiology and prevalence across different diagnoses and mood states are still poorly understood. Actigraphy allows unbiased, objective, and naturalistic assessment of physical activity as a marker of psychomotor slowing. Yet, the true effect-sizes remain unclear as recent, large systematic reviews are missing. We conducted a novel meta-analysis on actigraphically measured slowing in depression with strict inclusion and exclusion criteria for diagnosis ascertainment and sample duplications. Medline/PubMed and Web-of-Science were searched with terms combining mood-keywords and actigraphy-keywords until September 2021. Original research measuring actigraphy for ⩾24 h in at least two groups of depressed, remitted, or healthy participants and applying operationalized diagnosis was included. Studies in somatically ill patients, N < 10 participants/group, and studies using consumer-devices were excluded. Activity-levels between groups were compared using random-effects models with standardized-mean-differences and several moderators were examined. In total, 34 studies (n = 1804 patients) were included. Patients had lower activity than controls [standardized mean difference (s.m.d.) = -0.78, 95% confidence interval (CI) -0.99 to -0.57]. Compared to controls, patients with unipolar and bipolar disorder had lower activity than controls whether in depressed (unipolar: s.m.d. = -0.82, 95% CI -1.07 to -0.56; bipolar: s.m.d. = -0.94, 95% CI -1.41 to -0.46), or remitted/euthymic mood (unipolar: s.m.d. = -0.28, 95% CI -0.56 to 0.0; bipolar: s.m.d. = -0.92, 95% CI -1.36 to -0.47). None of the examined moderators had any significant effect. To date, this is the largest meta-analysis on actigraphically measured slowing in mood disorders. They are associated with lower activity, even in the remitted/euthymic mood-state. Studying objective motor behavior via actigraphy holds promise for informing screening and staging of affective disorders.
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