ArticleCommunications biology2022
The early-life exposome modulates the effect of polymorphic inversions on DNA methylation.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.Reproductive biology and endocrinology : RB&E · 2025Article
- Epigenetic state and gene expression remain stable after CRISPR/Cas-mediated chromosomal inversions.The New phytologist · 2025Article
- Defective X-chromosome inactivation and cancer risk in women.Communications biology · 2025Article
- Impact of Z chromosome inversions on gene expression in testis and liver tissues in the zebra finch.Molecular ecology · 2024Article
- Age at separation, residential mobility, and depressive symptoms among twins in late adolescence and young adulthood: a FinnTwin12 cohort study.BMC public health · 2024Article
- Decoding depression by exploring the exposome-genome edge amidst COVID-19 lockdown.Scientific reports · 2024Article
- Impact of tobacco, alcohol, and marijuana on genome-wide DNA methylation and its relationship with hypertension.Epigenetics · 2023Article
- Speed reading the epigenome and genome.Nature biotechnology · 2023Article
- Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
24 authors at 10 institutions in 6 countries.
Funding
Abstract
Polymorphic genomic inversions are chromosomal variants with intrinsic variability that play important roles in evolution, environmental adaptation, and complex traits. We investigated the DNA methylation patterns of three common human inversions, at 8p23.1, 16p11.2, and 17q21.31 in 1,009 blood samples from children from the Human Early Life Exposome (HELIX) project and in 39 prenatal heart tissue samples. We found inversion-state specific methylation patterns within and nearby flanking each inversion region in both datasets. Additionally, numerous inversion-exposure interactions on methylation levels were identified from early-life exposome data comprising 64 exposures. For instance, children homozygous at inv-8p23.1 and higher meat intake were more susceptible to TDH hypermethylation (P = 3.8 × 10
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